Pharmacotherapy for the core symptoms of autism spectrum disorder.

IF 4.7 3区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Peiying Tan, Xiaolin Shen, Lizhang Zeng, Xuchu Weng, Hongyan Geng
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引用次数: 0

Abstract

Autism spectrum disorder (ASD) is a range of neurodevelopmental diseases characterized by social dysfunction and stereotypic behaviors. The etiology of ASD remains largely unexplored, resulting in a diverse array of described clinical manifestations and varying degrees of severity. Currently, there are no drugs approved by a supervisory organization that can effectively treat the core symptoms of ASD. Childhood and adolescence are crucial stages for making significant achievements in ASD treatment, necessitating the development of drugs specifically for these periods. Based on the drug targets and mechanisms of action, it can be found that atypical psychotropic medications, anti-inflammatory and antioxidant medications, hormonal medications, ion channel medications, and gastrointestinal medications have shown significant improvement in treating the core symptoms of ASD in both children and adolescents. In addition, comparisons of drugs within the same category regarding efficacy and safety have been made to identify better alternatives and promote drug development. While further evaluation of the effectiveness and safety of these medications is needed, they hold great potential for widespread application in the clinical treatment of the principal symptoms of ASD.

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来源期刊
Journal of Zhejiang University SCIENCE B
Journal of Zhejiang University SCIENCE B 生物-生化与分子生物学
CiteScore
8.70
自引率
13.70%
发文量
2125
审稿时长
3.0 months
期刊介绍: Journal of Zheijang University SCIENCE B - Biomedicine & Biotechnology is an international journal that aims to present the latest development and achievements in scientific research in China and abroad to the world’s scientific community. JZUS-B covers research in Biomedicine and Biotechnology and Biochemistry and topics related to life science subjects, such as Plant and Animal Sciences, Environment and Resource etc.
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