Correction to Sleep Quality Improvements After MDMA-Assisted Psychotherapy for the Treatment of Posttraumatic Stress Disorder

Abstract

Ponte, L., Jerome, L., Hamilton, S., Mithoefer, M. C., Yazar-Klosinski, B. B., Vermetten, E., & Feduccia, A. A. (2021). Sleep quality improvements after MDMA-assisted psychotherapy for the treatment of posttraumatic stress disorder. Journal of Traumatic Stress, 34(4), 851–863.

Description and explanation for this correction

During the MP-4 study (CT.gov Identifier: NCT01958593), which took place between October 2014 and October 2016, there was an ethical violation resulting in a deviation from the protocol by a pair of participating therapists with one of the participants. The pair treated four of six participants in total in the MP-4 study out of the 68 participants included in the pooled analysis reported in the original manuscript.

Due to the aforementioned ethical violation, data from all four participants treated by the pair of therapists have been removed from analysis in this publication correction. The removal of the data does not compromise the conclusions.

Summary of corrections made

In METHODS under “Participants and procedure,” the following text was added at the end of Paragraph 1: “During the MP-4 study, there was an ethical violation by a pair of participating therapists that resulted in a deviation from the protocol. Data from all the four participants treated by this pair were removed, and all analyses were updated to reflect this change. Additional details are provided in the Supplementary Materials.”

Table 1 was revised due to removal of the four participants (all changed data are highlighted below).

Table 2 was revised due to removal of the four participants (all changed data are highlighted below). The overall results reported in the table are consistent with the original report.

In Figure 3, the graph for the change in CAPS-IV scores was revised due to removal of the four participants and reanalysis. The original Pearson's correlation values in the footnote remained significant following removal of the four MP-4 participants.

Note. The change in CAPS-IV and PSQI scores from Baseline to treatment exit (TE; n = 54) was significantly correlated, r = .372, p = .006.

Values in Table 3 were updated following the reanalysis, including the data on the percentage of participants with a drop of 3 points or more in PSQI total score (all changed data are highlighted below). After reanalysis, the majority of participants experienced a clinically significant improvement in sleep quality from baseline to 12-month follow-up, which is consistent with the results in the original report.

The table in the Supplementary Materials was updated due to the removal of the four participants (all changed data are highlighted below). There were no changes to the number of participants wreceiving sleep aids on the night of experimental sessions during the blinded segment. Only slight changes to the percentages were made to reflect a smaller population after removal of the participants.

Supplemental Table.

Number of participants who received a sleep aid on the night of an experimental session during the blinded segment.

We apologize for this error.