Lyna Mtimet, Lucas Boussingault, Dina Aktas, Margot Fontaine, Carmen Orte Cano, Gwendoline Diet, Clement Lenoir, Makiko Miyamoto, Elisa Cinotti, Linda Tognetti, Alessandra Cartocci, Pietro Rubegni, Susana Puig, Josep Malvehy, Javiera Perez-Anker, Jean-Luc Perrot, Véronique Del Marmol, Mariano Suppa
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引用次数: 0
Abstract
Introduction: Line-field confocal optical coherence tomography (LC-OCT) represents one of the newest non-invasive in vivo skin imaging techniques. Previous studies described morphologic criteria of basal cell carcinoma (BCC) under LC-OCT examination. Preliminary data on LC-OCT diagnostic performance for BCC have recently been published but showed only a modest improvement compared to dermoscopy, possibly due to study limitations.
Objectives: The main objective of this study was to find diagnostic performance parameters of LC-OCT for differentiating BCC from its clinical/dermoscopic mimickers and for discriminating among BCC subtypes. An additional objective was to suggest a simple, user-friendly diagnostic algorithm based on the most powerful LC-OCT features in the field of BCC and its imitators.
Materials and methods: Equivocal BCC lesions imaged with an LC-OCT device prior to biopsy/excision were included. Three observers blinded for histopathological diagnosis retrospectively formulated clinical, dermoscopic and LC-OCT diagnoses and evaluated LC-OCT features for each study lesion.
Results: A total of 303 lesions (173 BCCs and 130 non-BCCs) from 225 patients were included. For the differentiation of BCC from BCC imitators, the use of LC-OCT increased the diagnostic accuracy compared to clinical examination by 24% and compared to dermoscopy by 12%. For the discrimination of sBCC from other BCC subtypes, LC-OCT increased the diagnostic accuracy compared to clinical examination by 18% and compared to dermoscopy by 12%. The presence of lobule with millefeuille pattern was a significant feature for BCC diagnosis. Lobule shape and location allowed BCC subtype discrimination.
Conclusions: The accuracy of BCC diagnosis can be increased by at least 12% with the use of LC-OCT compared to clinical and dermoscopic examinations alone, both in terms of BCC differentiation from clinical/dermoscopic imitators and in terms of BCC-subtype discrimination. A diagnostic algorithm based on significant features for BCC diagnosis is proposed, for which further validation is required.
期刊介绍：
The Journal of the European Academy of Dermatology and Venereology (JEADV) is a publication that focuses on dermatology and venereology. It covers various topics within these fields, including both clinical and basic science subjects. The journal publishes articles in different formats, such as editorials, review articles, practice articles, original papers, short reports, letters to the editor, features, and announcements from the European Academy of Dermatology and Venereology (EADV).
The journal covers a wide range of keywords, including allergy, cancer, clinical medicine, cytokines, dermatology, drug reactions, hair disease, laser therapy, nail disease, oncology, skin cancer, skin disease, therapeutics, tumors, virus infections, and venereology.
The JEADV is indexed and abstracted by various databases and resources, including Abstracts on Hygiene & Communicable Diseases, Academic Search, AgBiotech News & Information, Botanical Pesticides, CAB Abstracts®, Embase, Global Health, InfoTrac, Ingenta Select, MEDLINE/PubMed, Science Citation Index Expanded, and others.
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