Least significant change with repeat bioelectrical impedance analysis measurements in children with metabolic dysfunction–associated steatotic liver disease: A descriptive cohort study

IF 3.2 3区医学 Q2 NUTRITION & DIETETICS

Journal of Parenteral and Enteral Nutrition Pub Date : 2024-12-03 DOI:10.1002/jpen.2706

Alexandria Speakman DO, Kathryn Hitchcock MS, RD, Emily Romantic RD, Venancio Quiambao RD, Abigail Lepolt RD, CSP, Ana Catalina Arce-Clachar MD, Kristin Bramlage MD, Lin Fei PhD, Qin Sun MS, Stavra Xanthakos MD, MS, Marialena Mouzaki MD, MSc

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引用次数: 0

Abstract

Background

Bioelectrical impedance is used clinically to assess body composition. To determine true (rather than chance/measurement error) change in bioelectrical impedance analysis measurements over time, it is necessary to know their least significant change. Least significant change represents values exceeding the 95% prediction interval of the precision error of repeat measurements. The least significant change of repeat bioelectrical impedance analysis measurements in children with obesity and metabolic dysfunction–associated steatotic liver disease is currently unknown.

Methods

This is a prospective, single-center, descriptive cohort study in youth 6–20 years of age with obesity and metabolic dysfunction–associated steatotic liver disease. Two same-day bioelectrical impedance analysis measurements were performed on a multifrequency, octopolar device (InBody 370). Fat mass and fat-free mass were adjusted for age using respective indices (dividing by height squared). Fasting status was determined by patient report. Descriptive statistics (medians with interquartile ranges and means with standard deviations and proportions) were used; the least significant change between repeat measurements with precision interval was calculated.

Results

We recruited 43 patients (81% male; 33% Hispanic; median age: 14 years [interquartile range: 11–16]; median body mass index z score: 2.31 [interquartile range: 2.84–2.65]). A total of 60% were fasting, for a median of 12 h. The least significant change of fat mass index was 0.5 (precision interval: −0.4 to 0.5) kg/m², fat-free mass index was 0.3 (precision interval: −0.3 to 0.3) kg/m², and body fat percent was 1.5% (precision interval: −1.3 to 1.50). Fasting status affected least significant change measurements.

Conclusion

In youth with obesity and metabolic dysfunction–associated steatotic liver disease, repeat bioelectrical impedance analysis measurements beyond least significant change and precision interval determined in this study likely represent true changes in body composition over time, vs measurement error.

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重复生物电阻抗分析测量在代谢功能障碍相关脂肪变性肝病儿童中最不显著的变化：一项描述性队列研究。

背景：生物电阻抗在临床上用于评估身体成分。为了确定生物电阻抗分析测量随时间的真实（而不是偶然/测量误差）变化，有必要知道它们的最不显著变化。最不显著变化表示超过重复测量精度误差95%预测区间的值。在肥胖和代谢功能障碍相关的脂肪变性肝病儿童中，重复生物电阻抗分析测量的最不显著变化目前尚不清楚。方法：这是一项前瞻性、单中心、描述性队列研究，研究对象为6-20岁的肥胖和代谢功能障碍相关的脂肪变性肝病青年。在多频八爪形装置（InBody 370）上进行了两次同日生物电阻抗分析测量。使用相应的指数（除以身高的平方）调整脂肪质量和无脂肪质量。空腹状态由患者报告确定。采用描述性统计（中位数为四分位数范围，平均值为标准差和比例）；以精度区间计算重复测量之间的最小显著变化。结果：我们招募了43例患者(81%为男性；33%的西班牙裔;中位年龄：14岁[四分位数范围：11-16]；身体质量指数z得分中位数：2.31[四分位数范围：2.84-2.65])。60%的患者禁食，平均时间为12小时。脂肪质量指数变化最不显著的是0.5（精确区间：-0.4 ~ 0.5）kg/m2，无脂质量指数变化最不显著的是0.3（精确区间：-0.3 ~ 0.3）kg/m2，体脂率变化最不显著的是1.5%（精确区间：-1.3 ~ 1.50）。禁食状态对测量结果影响最小。结论：在患有肥胖和代谢功能障碍相关脂肪变性肝病的青少年中，重复生物电阻抗分析测量超过本研究确定的最不显著变化和精度区间可能代表身体成分随时间的真实变化，而不是测量误差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Parenteral and Enteral Nutrition 医学-营养学

CiteScore

7.80

自引率

8.80%

发文量

161

审稿时长

6-12 weeks

期刊介绍： The Journal of Parenteral and Enteral Nutrition (JPEN) is the premier scientific journal of nutrition and metabolic support. It publishes original peer-reviewed studies that define the cutting edge of basic and clinical research in the field. It explores the science of optimizing the care of patients receiving enteral or IV therapies. Also included: reviews, techniques, brief reports, case reports, and abstracts.