Assessment of Lipid Profile in Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis.

IF 2.7 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine Pub Date : 2025-01-01 Epub Date: 2024-12-01 DOI:10.1111/jop.13596

Shruti Gupta, Deepti Sharma, Anita Hooda, Mala Kamboj

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引用次数: 0

Abstract

Background: An altered blood lipid profile has been considered as a diagnostic and/or prognostic marker for cancer. Since oral cancer is usually preceded by oral potentially malignant disorders (OPMDs) and share common etiopathogenesis, thus researchers have tried to explore the role of blood lipid profile as a marker for OPMDs; however, no consensus has been made regarding the utilization of serum lipid profile as a biomarker for oral submucous fibrosis (OSMF). Thus, the present article aimed to validate serum lipid profile as a biomarker for OSMF.

Methodology: PubMed, Scopus, Google Scholar and Clinical key databases were searched for relevant articles. Thirty-six studies that met the eligibility criteria were included for qualitative review, however, out of these, 27 studies with specific data for OSMF and the control group were included in the meta-analysis.

Results: A significant reduction in very low-density lipoprotein (p = 0.042), low density lipoprotein (p = 0.006), high density lipoprotein (p = 0.020), triglyceride (p = 0.049) and total cholesterol (p = 0.009) levels in blood were observed in OSMF patients in comparison to healthy controls whereas no significant difference was seen in contrast to oral squamous cell carcinoma patients.

Conclusion: Although a significant alteration was observed in lipid levels in OSMF patients, considerable heterogeneity in all the studied parameters implies that blood lipid profile could not be used as a reliable biomarker for OSMF and require further investigation.

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口腔黏膜下纤维化的脂质评估：系统回顾和荟萃分析。

背景：血脂变化被认为是癌症的诊断和/或预后指标。由于口腔癌通常伴有口腔潜在恶性疾病（OPMDs），并且具有共同的发病机制，因此研究人员试图探索血脂水平作为OPMDs的标志物的作用；然而，关于使用血清脂质谱作为口腔粘膜下纤维化（OSMF）的生物标志物尚未达成共识。因此，本文旨在验证血清脂质谱作为OSMF的生物标志物。方法：检索PubMed、Scopus、谷歌Scholar和Clinical关键数据库的相关文章。36项符合资格标准的研究被纳入定性评价，然而，其中27项具有OSMF和对照组特定数据的研究被纳入meta分析。结果：与健康对照组相比，OSMF患者血液中极低密度脂蛋白（p = 0.042）、低密度脂蛋白（p = 0.006）、高密度脂蛋白（p = 0.020）、甘油三酯（p = 0.049）和总胆固醇（p = 0.009）水平显著降低，而与口腔鳞状细胞癌患者相比，OSMF患者血液中极低密度脂蛋白（p = 0.042）、低密度脂蛋白（p = 0.006）和总胆固醇水平无显著差异。结论：尽管OSMF患者的血脂水平发生了显著变化，但所有研究参数存在相当大的异质性，这意味着血脂不能作为OSMF的可靠生物标志物，需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral Pathology & Medicine 医学-病理学

CiteScore

5.90

自引率

6.10%

发文量

121

审稿时长

4-8 weeks

期刊介绍： The aim of the Journal of Oral Pathology & Medicine is to publish manuscripts of high scientific quality representing original clinical, diagnostic or experimental work in oral pathology and oral medicine. Papers advancing the science or practice of these disciplines will be welcomed, especially those which bring new knowledge and observations from the application of techniques within the spheres of light and electron microscopy, tissue and organ culture, immunology, histochemistry and immunocytochemistry, microbiology, genetics and biochemistry.