Unveiling coagulation dysfunction in patients with COVID-19: a retrospective analysis.

Q3 Medicine
Ahmed Ali Jerah, Abdullah Farasani, Hisham Abu-Tawil, Hadi Kuriri, Manal Mohamed Elhassan Taha, Siddig Ibrahim Abdelwahab, Osama Albasheer
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Abstract

Coagulation dysfunction has emerged as a significant aspect of COVID-19 pathophysiology, with abnormal coagulation parameters observed in severe cases. This study aimed to investigate the predictive value of coagulation parameters, including prothrombin time (PT), activated partial thromboplastin time (PTT), and international normalized ratio (INR) for mortality in patients with COVID-19. A retrospective analysis was conducted on a cohort of patients diagnosed with COVID-19. Coagulation parameters, including PT, PTT, and INR, were measured upon admission. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive performance of these parameters. Sensitivity and specificity were calculated, and the area under the curve (AUC) values were determined. The analysis included 156 patients diagnosed with COVID-19. The t-test revealed a significant difference (P < 0.05) in PTT, PT, and INR. PTT demonstrated the highest predictive performance, with an AUC value of 0.68, indicating superior discrimination compared with PT and INR. PTT exhibited a sensitivity of 83% and a specificity of 46% for identifying deceased patients. These findings suggest that PTT may serve as a valuable prognostic marker of mortality risk in patients with COVID-19. Coagulation indicators, particularly PTT, predicted COVID-19 mortality. Monitoring coagulation markers may help stratify the risk and guide treatment. Further research and validation studies are needed to corroborate these findings and to establish the clinical importance of coagulation markers in COVID-19 therapy. COVID-19 coagulation dysfunction mechanisms must be understood in order to design targeted therapies to reduce thrombotic consequences.

揭示COVID-19患者凝血功能障碍:回顾性分析
凝血功能障碍已成为COVID-19病理生理的一个重要方面,重症患者可观察到凝血参数异常。本研究旨在探讨凝血酶原时间(PT)、活化部分凝血活酶时间(PTT)和国际标准化比值(INR)对COVID-19患者死亡率的预测价值。对一组新冠肺炎确诊患者进行回顾性分析。入院时测量凝血参数,包括PT、PTT和INR。采用受试者工作特征(ROC)曲线分析评价这些参数的预测效果。计算灵敏度和特异度,并测定曲线下面积(AUC)值。该分析包括156名被诊断为COVID-19的患者。经t检验,PTT、PT、INR差异有统计学意义(P < 0.05)。PTT表现出最高的预测性能,AUC值为0.68,与PT和INR相比具有更好的辨别能力。PTT在识别死亡患者方面的敏感性为83%,特异性为46%。这些发现表明,PTT可能是COVID-19患者死亡风险的一个有价值的预后标志物。凝血指标,特别是PTT,可预测COVID-19死亡率。监测凝血指标可能有助于风险分层和指导治疗。需要进一步的研究和验证研究来证实这些发现,并确定凝血标志物在COVID-19治疗中的临床重要性。必须了解COVID-19凝血功能障碍机制,以便设计靶向治疗以减少血栓后果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Medicine and Life
Journal of Medicine and Life Medicine-Medicine (all)
CiteScore
1.90
自引率
0.00%
发文量
202
期刊介绍: The Journal of Medicine and Life publishes peer-reviewed articles from various fields of medicine and life sciences, including original research, systematic reviews, special reports, case presentations, major medical breakthroughs and letters to the editor. The Journal focuses on current matters that lie at the intersection of biomedical science and clinical practice and strives to present this information to inform health care delivery and improve patient outcomes. Papers addressing topics such as neuroprotection, neurorehabilitation, neuroplasticity, and neuroregeneration are particularly encouraged, as part of the Journal''s continuous interest in neuroscience research. The Editorial Board of the Journal of Medicine and Life is open to consider manuscripts from all levels of research and areas of biological sciences, including fundamental, experimental or clinical research and matters of public health. As part of our pledge to promote an educational and community-building environment, our issues feature sections designated to informing our readers regarding exciting international congresses, teaching courses and relevant institutional-level events.
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