Reid A Mitchell, Alanna S Hind, Olivia N Ferguson, Morgan Flynn, Jem Arnold, Satvir S Dhillon, Neil D Eves, A William Sheel, Jordan A Guenette
{"title":"Multidimensional assessment of exertional dyspnea in young healthy males and females who select unsatisfied inspiration at peak exercise.","authors":"Reid A Mitchell, Alanna S Hind, Olivia N Ferguson, Morgan Flynn, Jem Arnold, Satvir S Dhillon, Neil D Eves, A William Sheel, Jordan A Guenette","doi":"10.1152/japplphysiol.00420.2024","DOIUrl":null,"url":null,"abstract":"<p><p>Historically, it was thought that healthy humans predominantly described their breathing as a sense of increased work or effort (W/E) during maximal exercise. However, emerging data shows that many healthy adults select unpleasant dyspnea descriptors such as \"unsatisfied inspiration\" (UI), with relatively more females selecting UI than males. We hypothesized that males and females who select UI would report higher dyspnea intensity ratings during exercise; select more distressing dyspnea qualities post-exercise; and have greater inspiratory constraints than those who do not. Sixty-four healthy, non-smokers (32M:32F; 23±5yr) completed questionnaires, pulmonary function tests, and maximal incremental cycling with detailed dyspnea evaluation. Males in UI and Non-UI subgroups reported similar Borg 0-10 dyspnea intensity ratings of W/E, UI, and unsatisfied expiration (UE) (all <i>P</i>>0.05). Females in the UI subgroup reported significantly higher UI and UE ratings than females in the Non-UI subgroup (both <i>P</i><0.01). Both UI subgroups reported greater air hunger, chest tightness, and mental breathing effort than Non-UI participants (all <i>P</i><0.05). In males only, masculine gender was negatively correlated (r=-0.402, <i>P</i>=0.02) and anxiety positively correlated (r=0.363, <i>P</i>=0.04) with submaximal UI ratings. Females with UI had smaller peak tidal volume (V<sub>T</sub>) (1.74 (0.32) vs 2.06 (0.33) L, <i>P</i>=0.03) than Non-UI females; and V<sub>T</sub> was negatively correlated with submaximal (r=-0.496, <i>P</i>=0.004) and peak (r=-0.495, <i>P</i>=0.004) UI ratings in all females. There were no differences in V<sub>T</sub> or correlations between V<sub>T</sub> and dyspnea in male subgroups. Absolute lung volumes and psychosocial factors appear important in understanding sex differences in the perception of UI during exercise.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of applied physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1152/japplphysiol.00420.2024","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Historically, it was thought that healthy humans predominantly described their breathing as a sense of increased work or effort (W/E) during maximal exercise. However, emerging data shows that many healthy adults select unpleasant dyspnea descriptors such as "unsatisfied inspiration" (UI), with relatively more females selecting UI than males. We hypothesized that males and females who select UI would report higher dyspnea intensity ratings during exercise; select more distressing dyspnea qualities post-exercise; and have greater inspiratory constraints than those who do not. Sixty-four healthy, non-smokers (32M:32F; 23±5yr) completed questionnaires, pulmonary function tests, and maximal incremental cycling with detailed dyspnea evaluation. Males in UI and Non-UI subgroups reported similar Borg 0-10 dyspnea intensity ratings of W/E, UI, and unsatisfied expiration (UE) (all P>0.05). Females in the UI subgroup reported significantly higher UI and UE ratings than females in the Non-UI subgroup (both P<0.01). Both UI subgroups reported greater air hunger, chest tightness, and mental breathing effort than Non-UI participants (all P<0.05). In males only, masculine gender was negatively correlated (r=-0.402, P=0.02) and anxiety positively correlated (r=0.363, P=0.04) with submaximal UI ratings. Females with UI had smaller peak tidal volume (VT) (1.74 (0.32) vs 2.06 (0.33) L, P=0.03) than Non-UI females; and VT was negatively correlated with submaximal (r=-0.496, P=0.004) and peak (r=-0.495, P=0.004) UI ratings in all females. There were no differences in VT or correlations between VT and dyspnea in male subgroups. Absolute lung volumes and psychosocial factors appear important in understanding sex differences in the perception of UI during exercise.
期刊介绍:
The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.