False-Positive Phosphatidylethanol Results Due to Blood Transfusion and Implications in the Process of Liver Transplantation Selection.

IF 4.2 3区医学 Q1 SUBSTANCE ABUSE

Journal of Addiction Medicine Pub Date : 2024-12-02 DOI:10.1097/ADM.0000000000001424

Jessica A S Wang, Giovani V Cruz Cruz, Akshay Shetty, Darlene Esquivel, Sammy Saab, Steven Shoptaw, Julio Meza

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Abstract

Abstract: Phosphatidylethanol (PEth) testing is becoming increasingly common as a tool to assess for alcohol consumption in the practice of addiction medicine. Its potential to be an objective measure of ethanol exposure is appealing; however, the field has yet to develop a complete understanding of the factors that can influence a PEth level. Here we describe 3 patient cases in which blood transfusion within the preceding 28 days was the reason that PEth studies were positive in patients undergoing liver transplant evaluation. These patients all had in-depth evaluations by physicians on an addiction medicine consult service and were believed abstinent from alcohol. In the field of liver transplant, even a mildly elevated PEth level can result in listing delay or even liver transplant candidacy denial. Further study is needed to understand how PEth is impacted by medical procedures and events such as blood transfusion if we are to maintain a just and ethical practice in the setting of addiction and transplant medicine.

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输血引起的磷脂酰乙醇假阳性结果及其在肝移植选择过程中的意义。

摘要：在成瘾医学实践中，磷脂酰乙醇（PEth）检测作为一种评估酒精消耗的工具越来越普遍。它有可能成为乙醇暴露的客观衡量标准，这很有吸引力；然而，该领域尚未完全了解可能影响白垩粉水平的因素。在这里，我们描述了3例患者，在接受肝移植评估的患者中，前28天内输血是导致PEth研究阳性的原因。这些病人都经过医生对成瘾药物咨询服务的深入评估，并被认为戒酒。在肝移植领域，即使是轻微升高的PEth水平也会导致上市延迟甚至肝移植候选被拒绝。如果我们要在成瘾和移植医学的背景下保持公正和道德的做法，就需要进一步研究以了解医疗程序和输血等事件如何影响PEth。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Addiction Medicine 医学-药物滥用

CiteScore

6.10

自引率

9.10%

发文量

260

审稿时长

>12 weeks

期刊介绍： The mission of Journal of Addiction Medicine, the official peer-reviewed journal of the American Society of Addiction Medicine, is to promote excellence in the practice of addiction medicine and in clinical research as well as to support Addiction Medicine as a mainstream medical sub-specialty. Under the guidance of an esteemed Editorial Board, peer-reviewed articles published in the Journal focus on developments in addiction medicine as well as on treatment innovations and ethical, economic, forensic, and social topics including: •addiction and substance use in pregnancy •adolescent addiction and at-risk use •the drug-exposed neonate •pharmacology •all psychoactive substances relevant to addiction, including alcohol, nicotine, caffeine, marijuana, opioids, stimulants and other prescription and illicit substances •diagnosis •neuroimaging techniques •treatment of special populations •treatment, early intervention and prevention of alcohol and drug use disorders •methodological issues in addiction research •pain and addiction, prescription drug use disorder •co-occurring addiction, medical and psychiatric disorders •pathological gambling disorder, sexual and other behavioral addictions •pathophysiology of addiction •behavioral and pharmacological treatments •issues in graduate medical education •recovery •health services delivery •ethical, legal and liability issues in addiction medicine practice •drug testing •self- and mutual-help.