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Characterization of a Time-Resolved, Real-Time Scintillation Dosimetry System for Ultra-High Dose-Rate Radiation Therapy Applications

IF 6.4 1区医学 Q1 ONCOLOGY

International Journal of Radiation Oncology Biology Physics Pub Date : 2024-11-28 DOI:10.1016/j.ijrobp.2024.11.092

Alexander Baikalov MS , Daline Tho PhD , Kevin Liu MS , Stefan Bartzsch PhD , Sam Beddar PhD , Emil Schüler PhD

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引用次数: 0

Abstract

Purpose

Scintillation dosimetry has promising qualities for ultra-high-dose-rate (UHDR) radiation therapy (RT), but no system has shown compatibility with mean dose rates (

\bar{D R}

) above 100 Gy/s and doses per pulse (

D_{p}

) exceeding 1.5 Gy typical of UHDR (FLASH)-RT. The aim of this study was to characterize a novel scintillation dosimetry system with the potential of accommodating UHDRs.

Methods and Materials

We undertook a thorough dosimetric characterization of the system on an UHDR electron beamline. The system's response as a function of dose,

\bar{D R}

D_{p}

, and the pulse dose-rate (

D R_{p}

) was investigated, as was the system's dose sensitivity (signal per unit dose) as a function of dose history. The capabilities of the system for time-resolved dosimetric readout were also evaluated.

Results

Within a tolerance of ±3%, the system exhibited dose linearity and was independent of

\bar{D R}

and

D_{p}

within the tested ranges of 1.8 to 1341 Gy/s and 0.005 to 7.68 Gy, respectively. A 6% reduction in the signal per unit dose was observed as

D R_{p}

was increased from 8.9e4 to 1.8e6 Gy/s. The dose delivered per integration window of the continuously sampling photodetector had to remain between 0.028 and 11.56 Gy to preserve a stable signal response per unit dose. The system accurately measured

D_{p}

of individual pulses delivered at up to 120 Hz. The day-to-day variation of the signal per unit dose in a reference setup varied by up to ±13% but remained consistent (<±2%) within each treatment day and showed no signal loss as a function of dose history.

Conclusions

With daily calibrations and

D R_{p}

-specific correction factors, the system reliably provides real-time, millisecond-resolved dosimetric measurements of pulsed conventional and UHDR beams from typical electron linacs, marking an important advancement in UHDR dosimetry and offering diverse applications to FLASH-RT and related fields.

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一种用于超高剂量率放射治疗的时间分辨、实时闪烁剂量测定系统的特性。

背景：闪烁剂量法对超高剂量率（UHDR）放射治疗（RT）有很好的质量，但没有系统显示出与100 Gy/s以上的平均剂量率（DR）和每脉冲剂量（Dp）超过1.5 Gy的典型UHDR (FLASH)-RT兼容。本研究的目的是表征一种新的闪烁剂量测定系统与适应uhdr的潜力。方法和材料：我们在UHDR电子束线上对该系统进行了彻底的剂量学表征。系统的响应作为剂量，DR， Dp和脉冲剂量率（DRp）的函数进行了研究，作为系统的剂量敏感性（每单位剂量的信号）作为剂量历史的函数。该系统的时间分辨剂量读数的能力也进行了评估。结果：在±3%的容差范围内，该体系呈现剂量线性，与DR和Dp无关，测试范围分别为1.8-1341 Gy/s和0.005-7.68 Gy。当DRp从8.94 Gy/s增加到1.8e6 Gy/s时，每单位剂量的信号减少6%。连续采样光电探测器的每个积分窗口所传递的剂量必须保持在0.028 ~ 11.56 Gy之间，以保持单位剂量的稳定信号响应。该系统精确测量了高达120hz的单个脉冲的Dp。参考装置中单位剂量信号的日常变化可达±13%，但保持一致（结论：通过每日校准和drp特异性校正因子，该系统可靠地提供来自典型电子直线加速器的脉冲常规和UHDR光束的实时、毫秒级分辨率剂量测量，标志着UHDR剂量测定的重要进步，并为FLASH-RT和相关领域提供了多种应用。）

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Radiation Oncology Biology Physics 医学-核医学

CiteScore

11.00

自引率

7.10%

发文量

2538

审稿时长

6.6 weeks

期刊介绍： International Journal of Radiation Oncology • Biology • Physics (IJROBP), known in the field as the Red Journal, publishes original laboratory and clinical investigations related to radiation oncology, radiation biology, medical physics, and both education and health policy as it relates to the field. This journal has a particular interest in original contributions of the following types: prospective clinical trials, outcomes research, and large database interrogation. In addition, it seeks reports of high-impact innovations in single or combined modality treatment, tumor sensitization, normal tissue protection (including both precision avoidance and pharmacologic means), brachytherapy, particle irradiation, and cancer imaging. Technical advances related to dosimetry and conformal radiation treatment planning are of interest, as are basic science studies investigating tumor physiology and the molecular biology underlying cancer and normal tissue radiation response.