Fibrinogen, FDP and D-Dimer as Potential Biomarkers for Disease Severity in Ulcerative Colitis: A Retrospective Study.

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of General Medicine Pub Date : 2024-11-26 eCollection Date: 2024-01-01 DOI:10.2147/IJGM.S477285

Wan Feng, Lei Zhu, Song Zhao, Kai Zheng, Luzhou Xu, Hong Shen

{"title":"Fibrinogen, FDP and D-Dimer as Potential Biomarkers for Disease Severity in Ulcerative Colitis: A Retrospective Study.","authors":"Wan Feng, Lei Zhu, Song Zhao, Kai Zheng, Luzhou Xu, Hong Shen","doi":"10.2147/IJGM.S477285","DOIUrl":null,"url":null,"abstract":"Purpose: Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease that primarily affects the large intestine. Coagulation abnormalities have been detected in UC patients. This study aimed to evaluate coagulation-related parameters in patients with UC.Patients and methods: A total of 364 UC patients were analyzed with 163 female and 201 male. Disease activity was determined according to the Truelove and Witts criteria. The fibrinogen (FIB), D-dimer, fibrin/fibrinogen degradation products (FDP), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels were evaluated.Results: We found higher D-dimer, FDP, FIB levels in severe UC compared with non-severe patients.The area under the curve (AUC) of D-dimer was 0.852 (95% CI 0.805 to 0.898) and the optimum cut-off point was 0.585, with a sensitivity of 80.6% and a specificity of 78.9%. Furthermore, D-dimer and FIB are positively correlated with ESR and CRP levels.Conclusion: Our results indicate that D-dimer, FDP, and FIB levels are potential biomarkers for disease severity in UC patients.","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5573-5579"},"PeriodicalIF":2.1000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607992/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of General Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/IJGM.S477285","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease that primarily affects the large intestine. Coagulation abnormalities have been detected in UC patients. This study aimed to evaluate coagulation-related parameters in patients with UC.

Patients and methods: A total of 364 UC patients were analyzed with 163 female and 201 male. Disease activity was determined according to the Truelove and Witts criteria. The fibrinogen (FIB), D-dimer, fibrin/fibrinogen degradation products (FDP), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels were evaluated.

Results: We found higher D-dimer, FDP, FIB levels in severe UC compared with non-severe patients.The area under the curve (AUC) of D-dimer was 0.852 (95% CI 0.805 to 0.898) and the optimum cut-off point was 0.585, with a sensitivity of 80.6% and a specificity of 78.9%. Furthermore, D-dimer and FIB are positively correlated with ESR and CRP levels.

Conclusion: Our results indicate that D-dimer, FDP, and FIB levels are potential biomarkers for disease severity in UC patients.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.