Global, regional, and national burden of liver cancer due to alcohol use, 1990-2021: results from the Global Burden of Disease study 2021.

IF 2.3 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

European Journal of Gastroenterology & Hepatology Pub Date : 2024-12-03 DOI:10.1097/MEG.0000000000002899

Qihong Wang, Wen Jia, Jiao Liu, Qian Zhao, Zhuo Yang

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引用次数: 0

Abstract

Background: Liver cancer is a major global health burden, with alcohol use being a well-established risk factor. This study aims to analyze the global, regional, and national incidence, prevalence, mortality, and disability-adjusted life years (DALYs) attributable to liver cancer due to alcohol use from 1990 to 2021.

Methods: Data on liver cancer due to alcohol use were collected from the 2021 Global Burden of Disease (GBD) study. The changing trend of liver cancer among alcohol users was described using the linear regression model. In addition, we employed a hierarchical cluster analysis to study the evolving patterns across diverse GBD regions and conducted a frontier analysis to explore the nexus between the burden and sociodemographic progress.

Results: In 2021, alcohol-related liver cancer globally accounted for 99 544 incidence cases, 132 033 prevalence cases, 92 228 death cases, and 2 316 027 DALYs cases. Males and middle-aged adults emerged as high-risk populations, while regions with a higher sociodemographic index (SDI) were identified as high-risk areas. From 1990 to 2021, both the number of cases and age-standardized rates (ASRs) increased. Our frontier analysis revealed unattained health gains between 1990 and 2021, highlighting disparities in disease burden among countries with varying SDI levels. This analysis further demonstrated an inverse correlation between SDI and alcohol-related liver cancer ASRs, with the ASRs stabilizing once the SDI exceeded 0.40.

Conclusion: Alcohol use is a significant contributor to the global burden of liver cancer. Comprehensive policies and interventions targeting alcohol use are needed to reduce the burden of alcohol-related liver cancer.

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1990-2021年全球、区域和国家酒精使用导致的肝癌负担：来自2021年全球疾病负担研究的结果

背景：肝癌是一个主要的全球健康负担，酒精使用是一个公认的危险因素。本研究旨在分析1990年至2021年全球、地区和国家因饮酒导致肝癌的发病率、患病率、死亡率和残疾调整生命年（DALYs）。方法：从2021年全球疾病负担（GBD）研究中收集酒精使用导致肝癌的数据。用线性回归模型描述了饮酒人群肝癌发生的变化趋势。此外，我们采用层次聚类分析研究了不同GBD地区的演变模式，并进行了前沿分析，探讨了GBD负担与社会人口发展之间的关系。结果：2021年，全球酒精相关性肝癌发病99 544例，流行132 033例，死亡92 228例，失活2 316 027例。男性和中年人是高危人群，而社会人口指数（SDI）较高的地区被确定为高危地区。从1990年到2021年，病例数和年龄标准化率（asr）均有所增加。我们的前沿分析揭示了1990年至2021年间未实现的健康收益，突出了不同SDI水平国家之间疾病负担的差异。该分析进一步证明了SDI与酒精相关性肝癌asr之间的负相关，当SDI超过0.40时，asr趋于稳定。结论：酒精使用是全球肝癌负担的一个重要因素。需要针对酒精使用的综合政策和干预措施，以减轻酒精相关肝癌的负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Gastroenterology & Hepatology 医学-胃肠肝病学

CiteScore

4.40

自引率

4.80%

发文量

269

审稿时长

1 months

期刊介绍： European Journal of Gastroenterology & Hepatology publishes papers reporting original clinical and scientific research which are of a high standard and which contribute to the advancement of knowledge in the field of gastroenterology and hepatology. The journal publishes three types of manuscript: in-depth reviews (by invitation only), full papers and case reports. Manuscripts submitted to the journal will be accepted on the understanding that the author has not previously submitted the paper to another journal or had the material published elsewhere. Authors are asked to disclose any affiliations, including financial, consultant, or institutional associations, that might lead to bias or a conflict of interest.