Differences in target organ damage in individuals with intermediate hyperglycemia and type 2 diabetes identified by 1-hour plasma glucose during an oral glucose tolerance test.

IF 6.1 3区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Chiara Maria Assunta Cefalo, Alessia Riccio, Teresa Vanessa Fiorentino, Elena Succurro, Gaia Chiara Mannino, Maria Perticone, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti
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引用次数: 0

Abstract

Aims: The International Diabetes Federation (IDF) has recently recommended determination of 1-hour glucose during an oral glucose tolerance test (OGTT) to diagnose intermediate hyperglycemia (IH) and type 2 diabetes (T2D). Herein, we investigated the implications of IDF recommendation for characterizing the risk of cardiovascular target organ damage including left ventricular mass normalized by body surface area (LVM index [LVMI]), and myocardial mechano-energetic efficiency normalized by LVM (MEEi) in individuals with IH and T2D.

Methods: LVMI, and MEEi were assessed in 1847 adults classified on the basis of fasting, 1-hour and 2- hour glucose during an OGTT according to the IDF recommendation as having normal glucose tolerance (NGT, n = 736), isolated impaired fasting glucose (iIFG, n = 105), IH (n = 676), and newly diagnosed T2D (n = 330).

Results: As compared with NGT group, individuals with either IH or T2D exhibited significantly higher LVMI (97 ± 26, 109 ± 30, and 116 ± g/m2, P < 0.001, respectively), and a decrease in MEEi (0.42 ± 0.11, 0.37 ± 0.10, and 0.35 ± 0.11 ml/sec*g-1, P < 0.001, respectively). LVMI, and MEEi did not differ between NGT and iIFG groups.

Conclusion: The thresholds of 1-hour post-load glucose proposed by IDF as diagnostic criteria for IH and T2D are capable of detecting individuals at risk of cardiovascular target organ damage.

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来源期刊
Diabetes research and clinical practice
Diabetes research and clinical practice 医学-内分泌学与代谢
CiteScore
10.30
自引率
3.90%
发文量
862
审稿时长
32 days
期刊介绍: Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.
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