A Review Article: The Relationship Between Obesity and Colorectal Cancer.

IF 5.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Diabetes Reports Pub Date : 2024-12-02 DOI:10.1007/s11892-024-01556-0

Lily Nguyen, Skandan Shanmugan

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引用次数: 0

Abstract

Purpose of review: This article aims to review the recent literature assessing the relationship between obesity and colorectal carcinogenesis, the effect of obesity on the treatment of colorectal cancer (CRC), tools available to help augment the increased risk, and outcomes for patients who are affected by both obesity and colorectal cancer.

Recent findings: The biochemical mechanisms contributing to CRC carcinogenesis are not well understood but are suspected to be related to adipose tissue leading to a pro-inflammatory state and changes in the gut microbiome. Individuals with obesity are at higher risk for CRC development, worse oncologic outcomes, and increased rates of post-operative complications. Bariatric surgery decreases CRC risk but results with GLP-1 agonists are heterogeneous. Prehabilitation is the only weight loss method that has been demonstrated to decrease risks of post-operative morbidity in this population. Obesity augments CRC risk and outcomes. There are persistent knowledge gaps in etiology and epidemiology for the increased CRC risk in obese patients and more research is required to identify the therapeutic advantage of weight loss on CRC risk.

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综述：肥胖与结直肠癌的关系。

综述目的：本文旨在回顾最近的文献，评估肥胖与结直肠癌发生之间的关系，肥胖对结直肠癌治疗的影响，可用的工具来帮助增加风险，以及肥胖和结直肠癌患者的结局。最近发现：促进结直肠癌癌变的生化机制尚不清楚，但怀疑与脂肪组织导致促炎状态和肠道微生物组变化有关。肥胖患者发生结直肠癌的风险更高，肿瘤预后更差，术后并发症发生率更高。减肥手术降低结直肠癌的风险，但GLP-1激动剂的结果是不均匀的。在这一人群中，预康复是唯一被证明可以降低术后发病率的减肥方法。肥胖增加结直肠癌的风险和结果。在肥胖患者CRC风险增加的病因学和流行病学方面一直存在知识空白，需要更多的研究来确定减肥对CRC风险的治疗优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Diabetes Reports 医学 -

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of diabetes epidemiology, pathophysiology, and management. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.