Effects of Physical Activity, VO_2max, and Visfatin on Relationship Between BMI and Chronic Inflammation.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2024-11-26 eCollection Date: 2024-01-01 DOI:10.2147/DMSO.S473266

Liqiang Su, Shouzhi Wu, Jinmei Fu, Shunli Sun

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引用次数: 0

Abstract

Purpose: This study aims to explore the relationship between BMI and chronic inflammation and to investigate the interaction and mediation of physical activity (PA), cardiopulmonary function, and visfatin.

Methods: A total of 119 participants were included in the study, 60 in the obesity group, 30 in the normal weight group, and 29 in the overweight group. PA, VO_2max, visfatin, high-sensitivity C-reactive protein (hs-CRP), and four blood lipid indices (TC, TG, HDLC, LDLC) were analyzed. Regression analysis was used to understand the effect of BMI on chronic inflammation. Covariate analysis was conducted to screen effective covariates affecting BMI to predict chronic inflammation and test the interaction and intermediary role of effective covariates.

Results: The increase in BMI could aggravate chronic inflammation. PA, VO_2max, and visfatin had interactive effects on BMI affecting chronic inflammation, and visfatin played an intermediary role in BMI affecting chronic inflammation. The effect value of BMI on chronic inflammation in terms of low PA was 3.5 times higher than that of high PA, that of low VO_2max was 2.8 times higher than that of high VO_2max, and that of high visfatin was 3.65 times higher than that of low visfatin. Approximately 19.35% of the effect was mediated by visfatin.

Conclusion: An increase in BMI can aggravate chronic inflammation. Increases in PA and VO_2max can alleviate chronic inflammation, and visfatin plays a positive mediating role.

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体力活动、最大摄氧量和脂肪素对BMI和慢性炎症关系的影响。

目的：本研究旨在探讨BMI与慢性炎症的关系，并探讨体力活动（PA）、心肺功能和脂肪素之间的相互作用和中介作用。方法：共纳入119例受试者，其中肥胖组60例，正常体重组30例，超重组29例。分析PA、VO2max、visfatin、高敏c反应蛋白（hs-CRP）及4项血脂指标（TC、TG、HDLC、LDLC）。采用回归分析了解BMI对慢性炎症的影响。通过协变量分析筛选影响BMI预测慢性炎症的有效协变量，检验有效协变量的相互作用和中介作用。结果：BMI升高可加重慢性炎症。PA、VO2max和visfatin对BMI影响慢性炎症具有交互作用，visfatin在BMI影响慢性炎症中起中介作用。BMI在低PA下对慢性炎症的影响值是高PA的3.5倍，低VO2max是高VO2max的2.8倍，高visfatin是低visfatin的3.65倍。约19.35%的效果是由visfatin介导的。结论：BMI升高可加重慢性炎症。PA和VO2max的增加可以缓解慢性炎症，visfatin起着积极的中介作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.