Live attenuated goatpox vaccination in pregnant Murcia-Granada goats: dosage implications and outcomes.

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES
Hossein Esmaeili, Mohammadreza Ghorani, Seyed Mehdi Joghataei, Sergio Villanueva-Saz, Delia Lacasta
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引用次数: 0

Abstract

Background: Infectious diseases, particularly the Goatpox virus (GTPV) from the Poxviridae family, significantly impact livestock health and agricultural economies, especially in developing regions. Recent GTPV outbreaks in previously eradicated areas underscore the need for effective control measures, with vaccination being the most reliable strategy. This study investigates the effects of administering standard and double doses of live attenuated goatpox vaccine in pregnant Murcia-Granada goats, a non-native breed in Iran, to determine optimal vaccination protocols.

Results: In 2018, 400 healthy and pregnant Murcia Granada goats imported from Spain were divided into groups of 200 and vaccinated with either a standard dose (0.5 ml) or a double dose (single 0.9 ml injection) of live attenuated goatpox vaccine. Post-vaccination, the goats were monitored daily for clinical signs of infection, with samples collected for PCR analysis to detect the presence of GTPV strains. In group A, which received the standard vaccine dose, no abortions or vaccine-related side effects were observed, and body temperatures remained normal. In group B, administered a double dose, 37% of the goats experienced abortions, displaying signs of GTPV infection, such as skin lesions (pox lesions) and increased body temperatures. Molecular analysis confirmed the vaccine strain of GTPV as the infection source, ruling out external contamination. Statistical analysis showed no significant differences in abortion rates concerning gestational age or t he age of the pregnant goats.

Conclusion: The study highlights the importance of adhering to standard vaccine dosages in pregnant Murcia Granada goats to prevent adverse outcomes like abortions. This study emphasizes the necessity to review and revise vaccination protocols tailored to specific breeds and varying maintenance conditions, including pregnancy and outbreak scenarios. These findings stress the necessity for cautious and tailored vaccination strategies to ensure the safety and efficacy of vaccines in different goat breeds.

怀孕穆尔西亚-格拉纳达山羊减毒山羊痘活疫苗接种:剂量影响和结果。
背景:传染性疾病,特别是痘病毒科的山羊痘病毒(GTPV),严重影响牲畜健康和农业经济,特别是在发展中地区。最近在以前被根除的地区暴发的GTPV突出表明需要采取有效的控制措施,而疫苗接种是最可靠的战略。本研究调查了对怀孕的穆尔西亚-格拉纳达山羊(伊朗的一种非本地品种)施用标准剂量和双倍剂量减毒山羊痘活疫苗的效果,以确定最佳接种方案。结果:2018年,从西班牙进口的健康怀孕穆尔西亚格兰纳达山羊400只,每组200只,分别接种标准剂量(0.5 ml)和双剂量(单次注射0.9 ml)羊痘减毒活疫苗。接种疫苗后,每天监测山羊的临床感染症状,收集样本进行PCR分析,以检测GTPV菌株的存在。在接受标准疫苗剂量的A组中,没有观察到流产或疫苗相关的副作用,体温保持正常。在B组,给予双倍剂量,37%的山羊流产,表现出GTPV感染的迹象,如皮肤损伤(痘损)和体温升高。分子分析证实GTPV疫苗株为传染源,排除了外源污染。统计分析显示,流产率与胎龄、胎龄无显著差异。结论:该研究强调了在怀孕的穆尔西亚格拉纳达山羊中坚持标准疫苗剂量以防止流产等不良后果的重要性。这项研究强调有必要审查和修订针对特定品种和不同维持条件(包括怀孕和疫情情况)量身定制的疫苗接种方案。这些发现强调有必要采取谨慎和量身定制的疫苗接种策略,以确保疫苗在不同山羊品种中的安全性和有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Veterinary Research
BMC Veterinary Research VETERINARY SCIENCES-
CiteScore
4.80
自引率
3.80%
发文量
420
审稿时长
3-6 weeks
期刊介绍: BMC Veterinary Research is an open access, peer-reviewed journal that considers articles on all aspects of veterinary science and medicine, including the epidemiology, diagnosis, prevention and treatment of medical conditions of domestic, companion, farm and wild animals, as well as the biomedical processes that underlie their health.
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