Deficits in prosodic speech-in-noise recognition in schizophrenia patients and its association with psychiatric symptoms.

IF 3.4 2区 医学 Q2 PSYCHIATRY
Shenglin She, Bingyan Gong, Qiuhong Li, Yu Xia, Xiaohua Lu, Yi Liu, Huawang Wu, Chao Wu, Yingjun Zheng
{"title":"Deficits in prosodic speech-in-noise recognition in schizophrenia patients and its association with psychiatric symptoms.","authors":"Shenglin She, Bingyan Gong, Qiuhong Li, Yu Xia, Xiaohua Lu, Yi Liu, Huawang Wu, Chao Wu, Yingjun Zheng","doi":"10.1186/s12888-024-06065-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Uncertainty in speech perception and emotional disturbances are intertwined with psychiatric symptoms. How prosody embedded in target speech affects speech-in-noise recognition (SR) and is related to psychiatric symptoms in patients with schizophrenia (SCHs) remains unclear. This study aimed to examine the neural substrates of prosodic SR deficits and their associations with psychiatric symptom dimensions in patients with schizophrenia.</p><p><strong>Methods: </strong>Fifty-four SCHs and 59 healthy control participants (HCs) completed the SR task (participants were required to identify the contents of the target pseudo-sentences expressed in neutral, happy, sad, angry, fearful, and disgusted prosody by actors), positive and negative syndrome scale (PANSS) assessment, and magnetic resonance imaging scanning. We examined the deficits of the six prosodic SRs in schizophrenia patients and their associations with brain gray matter volume (GMV) and psychiatric symptoms.</p><p><strong>Results: </strong>Negative emotional (sad, angry, fearful, and disgusted) prosodies of the target sentences worsened SR across groups. Both participant groups had equal SR between the neutral and happy prosody conditions. Compared to the anger and disgusted conditions, SCHs and HCs had better SR under sad and fearful conditions. Better prosodic SR was associated with shorter duration and lower local shimmer of target sentences. A partial least squares (PLS) component of GMV (covering 47 brain regions with group differences) was associated with six prosodic SRs. The happy SR was associated with the PANSS total, negative, and general scores, adjusting for covariates.</p><p><strong>Conclusions: </strong>Negative emotional prosodies of the target sentences dampened the recognition of the target sentences. The prosodic SR abnormalities in SCHs were associated with not only brain GMV reductions in the regions involved in the processing of sensorimotor, speech, and emotion but also with negative and general psychiatric symptoms. These findings suggest the possibility of improving negative symptoms by improving a happy SR in schizophrenia patients based on neuroplasticity.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"864"},"PeriodicalIF":3.4000,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607918/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12888-024-06065-8","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Uncertainty in speech perception and emotional disturbances are intertwined with psychiatric symptoms. How prosody embedded in target speech affects speech-in-noise recognition (SR) and is related to psychiatric symptoms in patients with schizophrenia (SCHs) remains unclear. This study aimed to examine the neural substrates of prosodic SR deficits and their associations with psychiatric symptom dimensions in patients with schizophrenia.

Methods: Fifty-four SCHs and 59 healthy control participants (HCs) completed the SR task (participants were required to identify the contents of the target pseudo-sentences expressed in neutral, happy, sad, angry, fearful, and disgusted prosody by actors), positive and negative syndrome scale (PANSS) assessment, and magnetic resonance imaging scanning. We examined the deficits of the six prosodic SRs in schizophrenia patients and their associations with brain gray matter volume (GMV) and psychiatric symptoms.

Results: Negative emotional (sad, angry, fearful, and disgusted) prosodies of the target sentences worsened SR across groups. Both participant groups had equal SR between the neutral and happy prosody conditions. Compared to the anger and disgusted conditions, SCHs and HCs had better SR under sad and fearful conditions. Better prosodic SR was associated with shorter duration and lower local shimmer of target sentences. A partial least squares (PLS) component of GMV (covering 47 brain regions with group differences) was associated with six prosodic SRs. The happy SR was associated with the PANSS total, negative, and general scores, adjusting for covariates.

Conclusions: Negative emotional prosodies of the target sentences dampened the recognition of the target sentences. The prosodic SR abnormalities in SCHs were associated with not only brain GMV reductions in the regions involved in the processing of sensorimotor, speech, and emotion but also with negative and general psychiatric symptoms. These findings suggest the possibility of improving negative symptoms by improving a happy SR in schizophrenia patients based on neuroplasticity.

精神分裂症患者噪音中韵律言语识别缺陷及其与精神症状的关系
背景:言语感知的不确定性和情绪障碍与精神症状交织在一起。目标言语中嵌入的韵律如何影响语音噪声识别(SR)以及与精神分裂症患者精神症状的关系尚不清楚。本研究旨在探讨精神分裂症患者节律性SR缺陷的神经基础及其与精神症状维度的关系。方法:54名自闭症儿童和59名健康对照者分别完成了SR任务(参与者被要求识别演员以中性、快乐、悲伤、愤怒、恐惧和厌恶的韵律表达的目标伪句的内容)、阳性和阴性综合征量表(PANSS)评估和磁共振成像扫描。我们研究了精神分裂症患者的6种节律性SRs缺陷及其与脑灰质体积(GMV)和精神症状的关系。结果:目标句子的负面情绪韵律(悲伤、愤怒、恐惧和厌恶)在组间恶化了SR。两个参与者组在中性和快乐韵律条件下的SR相等。与愤怒和厌恶条件相比,悲伤和恐惧条件下,高智商者和高智商者有更好的SR。较好的韵律SR与较短的持续时间和较低的局部闪烁有关。GMV的偏最小二乘(PLS)分量(覆盖47个脑区,组间差异)与6个韵律性sr相关。在调整协变量后,快乐的SR与PANSS总分、负得分和一般得分相关。结论:目标句的消极情绪韵律抑制了目标句的识别。SCHs的节律性SR异常不仅与感觉运动、言语和情绪处理相关区域的脑GMV减少有关,还与阴性和一般精神症状有关。这些发现表明,基于神经可塑性,通过改善精神分裂症患者的快乐SR来改善阴性症状的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
BMC Psychiatry
BMC Psychiatry 医学-精神病学
CiteScore
5.90
自引率
4.50%
发文量
716
审稿时长
3-6 weeks
期刊介绍: BMC Psychiatry is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of psychiatric disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信