Effect of a high-protein and low-glycaemic index diet during pregnancy in women with overweight or obesity on offspring metabolic health-A randomized controlled trial.

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2024-12-02 DOI:10.1111/ijpo.13191

Christina Sonne Mogensen, Faidon Magkos, Helle Zingenberg, Nina Rica Wium Geiker

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引用次数: 0

Abstract

Background: Maternal obesity and excessive weight gain during pregnancy are associated with higher birth weight and increased risk of childhood obesity.

Objective: This study investigated the effect of a high-protein and low-glycaemic-index (HPLGI) diet during pregnancy on offspring body composition and metabolic health.

Methods: We conducted a dietary intervention study in pregnant women with a pre-pregnancy BMI of 28-45 kg/m² who were randomly assigned to an HPLGI diet or a moderate-protein moderate-glycaemic-index (MPMGI) diet. A total of 208 offspring born to these women were followed-up from birth to 5 years of age.

Results: No differences were found on BMI z-scores at different ages; however, offspring born to women on the HPLGI diet exhibited 0.43 mmol/L higher glucose levels (p = 0.017) at birth compared with the MPMGI diet. At 3 years of age, HPLGI offspring had 0.09 mmol/L lower levels of HDL-cholesterol (p = 0.018) and 16% higher levels of triglycerides (p = 0.044). At 5 years of age, they had 0.25 mmol/L higher total cholesterol levels (p = 0.027) and 0.27 mmol/L higher LDL-cholesterol levels (p = 0.003) compared with the MPMGI diet.

Conclusion: An HPLGI diet during pregnancy may lead to adverse metabolic outcomes in the offspring, necessitating further investigation into long-term health implications.

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超重或肥胖妇女孕期高蛋白低血糖指数饮食对后代代谢健康的影响——一项随机对照试验

背景：孕妇肥胖和孕期体重过度增加与出生体重增加和儿童期肥胖风险增加有关。目的：研究妊娠期高蛋白低血糖指数（HPLGI）饮食对子代身体组成和代谢健康的影响。方法：我们对孕前BMI为28-45 kg/m2的孕妇进行了一项饮食干预研究，这些孕妇被随机分配到HPLGI饮食或中等蛋白质中等血糖指数（MPMGI）饮食中。这些妇女所生的208个孩子从出生到5岁都被跟踪调查。结果：不同年龄组BMI z-score差异无统计学意义；然而，与MPMGI饮食相比，HPLGI饮食的女性所生的后代出生时血糖水平高出0.43 mmol/L （p = 0.017）。3岁时，HPLGI后代的hdl -胆固醇水平降低0.09 mmol/L (p = 0.018)，甘油三酯水平升高16% （p = 0.044）。在5岁时，与MPMGI饮食相比，他们的总胆固醇水平高出0.25 mmol/L (p = 0.027)，低密度脂蛋白胆固醇水平高出0.27 mmol/L （p = 0.003）。结论：妊娠期间的高糖饮食可能会导致后代的不良代谢结果，有必要进一步研究其对长期健康的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.