{"title":"18F-sodium fluoride positron emission tomography is a sensitive imaging technique to detect atherosclerosis in Amazon parrots (Amazona spp).","authors":"Lucyanne Megan, Kelsey Brust, Matthieu Spriet, Pedro Ruivo, Marcel Gómez-Ponce, Hugues Beaufrère","doi":"10.2460/ajvr.24.10.0303","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate and establish a protocol for 18F-sodium fluoride (18F-NaF) PET scan imaging in Amazon parrots for atherosclerosis diagnosis.</p><p><strong>Methods: </strong>In this feasibility proof-of-concept study, 18F-NaF μPET scan and μCT scan were obtained on Hispaniolan (Amazona ventralis) and orange-winged Amazon parrots (A amazonica). A different μPET scan protocol was used for each species. Images were reviewed by 3 observers for arterial calcification and radiotracer uptake indicative of atherosclerosis. A blood lipid profile was also performed. A subset of Hispaniolan Amazon parrots were euthanized after completion of the study, and the heart and arteries were collected for histopathology.</p><p><strong>Results: </strong>10 adult Hispaniolan and 8 adult orange-winged Amazon parrots were scanned. Atherosclerotic lesions were detected on both μCT and μPET scan in various arteries. The presence of streak artifacts and increased noise on μCT scan limited the ability to detect high-attenuation areas of arteries and obtain observer consensus except for 1 case of severe arterial calcification. μPET scan was overall more sensitive, had higher interobserver agreement in lesion scoring, and detected a higher number of lesions in both species, including in coronary arteries. On histopathology on 5 Amazon parrots, the majority (5/6) of clinically relevant atherosclerotic lesions and some preatheromatous lesions (1/3) were identified on μPET scan. No association between atherosclerosis detection on μPET scan and the lipid profile was observed.</p><p><strong>Conclusions: </strong>This study established a safe and effective protocol for 18F-NaF molecular imaging of psittacine atherosclerosis, which proved to be more sensitive than CT scan.</p><p><strong>Clinical relevance: </strong>18F-sodium fluoride PET scan allows for a more reliable and earlier diagnosis of atherosclerotic lesions in Amazon parrots.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3000,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of veterinary research","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.2460/ajvr.24.10.0303","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To investigate and establish a protocol for 18F-sodium fluoride (18F-NaF) PET scan imaging in Amazon parrots for atherosclerosis diagnosis.
Methods: In this feasibility proof-of-concept study, 18F-NaF μPET scan and μCT scan were obtained on Hispaniolan (Amazona ventralis) and orange-winged Amazon parrots (A amazonica). A different μPET scan protocol was used for each species. Images were reviewed by 3 observers for arterial calcification and radiotracer uptake indicative of atherosclerosis. A blood lipid profile was also performed. A subset of Hispaniolan Amazon parrots were euthanized after completion of the study, and the heart and arteries were collected for histopathology.
Results: 10 adult Hispaniolan and 8 adult orange-winged Amazon parrots were scanned. Atherosclerotic lesions were detected on both μCT and μPET scan in various arteries. The presence of streak artifacts and increased noise on μCT scan limited the ability to detect high-attenuation areas of arteries and obtain observer consensus except for 1 case of severe arterial calcification. μPET scan was overall more sensitive, had higher interobserver agreement in lesion scoring, and detected a higher number of lesions in both species, including in coronary arteries. On histopathology on 5 Amazon parrots, the majority (5/6) of clinically relevant atherosclerotic lesions and some preatheromatous lesions (1/3) were identified on μPET scan. No association between atherosclerosis detection on μPET scan and the lipid profile was observed.
Conclusions: This study established a safe and effective protocol for 18F-NaF molecular imaging of psittacine atherosclerosis, which proved to be more sensitive than CT scan.
Clinical relevance: 18F-sodium fluoride PET scan allows for a more reliable and earlier diagnosis of atherosclerotic lesions in Amazon parrots.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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