Trends in Photopolymerization 3D Printing for Advanced Drug Delivery Applications.

IF 5.5 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-03 DOI:10.1021/acs.biomac.4c01004

Yu Hu, Zhi Luo, Yinyin Bao

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Abstract

Since its invention in the 1980s, photopolymerization-based 3D printing has attracted significant attention for its capability to fabricate complex microstructures with high precision, by leveraging light patterning to initiate polymerization and cross-linking in liquid resin materials. Such precision makes it particularly suitable for biomedical applications, in particular, advanced and customized drug delivery systems. This review summarizes the latest advancements in photopolymerization 3D printing technology and the development of biocompatible and/or biodegradable materials that have been used or shown potential in the field of drug delivery. The drug loading methods and release characteristics of the 3D printing drug delivery systems are summarized. Importantly, recent trends in the drug delivery applications based on photopolymerization 3D printing, including oral formulations, microneedles, implantable devices, microrobots and recently emerging systems, are analyzed. In the end, the challenges and opportunities in photopolymerization 3D printing for customized drug delivery are discussed.

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用于先进药物输送应用的光聚合3D打印趋势。

自20世纪80年代发明以来，基于光聚合的3D打印技术已经引起了人们的极大关注，因为它能够通过利用光图案来引发液体树脂材料的聚合和交联，以高精度制造复杂的微结构。这种精度使其特别适用于生物医学应用，特别是先进和定制的药物输送系统。本文综述了光聚合3D打印技术的最新进展，以及生物相容性和/或生物可降解材料的发展，这些材料已在药物输送领域得到应用或显示出潜力。综述了3D打印给药系统的载药方法和释放特性。重要的是，分析了基于光聚合3D打印的药物递送应用的最新趋势，包括口服配方、微针、植入式装置、微型机器人和最近出现的系统。最后，讨论了光聚合3D打印用于定制给药的挑战和机遇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.