Investigating the Mediating Role of Mental Disorders in the Relationship Between Early Sexual Intercourse and Intentional Self-Harm: A Two-Step and Multivariable Mendelian Randomization Study

IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES
Dameng Dong, Saboor Saeed, Rucheng Chen, An Chen, Weijun Zheng
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引用次数: 0

Abstract

Background

Epidemiological studies have established an association between early sexual intercourse and intentional self-harm. However, the causal mechanisms, particularly the role of mental health disorders, remain elusive.

Methods

In this Mendelian randomization (MR) study, we leveraged genome-wide association study data from multiple sources. Age at first sexual intercourse (AFSI) statistics were derived from the UK Biobank, encompassing up to 406,457 participants of European ancestry. Intentional self-harm (ISH) genome-wide association study (GWAS) data were obtained from the FinnGen Biobank, comprising 218,792 European-descent individuals. We investigated the causal relationship between AFSI and ISH and quantified the mediating effects of major depressive disorder (MDD; n = 173,005), schizophrenia (SCZ; n = 127,906), and attention deficit hyperactivity disorder (ADHD; n = 55,374). Both two-step and multivariable MR approaches were employed to estimate the mediation effects of these psychiatric disorders.

Results

The F-statistics of all retained SNPs are over 10, indicating our study has no weak instrument bias. The odds ratio (OR) indicated that early sexual intercourse substantially increases the risk of ISH (IVW: OR = 0.60, 95% CI = 0.54–0.66, p < 0.05). Specifically, MDD was found to mediate 31% of this effect and SCZ 12%, collectively accounting for 46% of the total effect.

Conclusions

Early sexual intercourse is associated with an increased risk of intentional self-harm, potentially mediated by psychiatric disorders. These findings emphasize the need for mental health screening and early intervention in adolescents with early sexual debuts.

Abstract Image

精神障碍在早期性行为与故意自残关系中的中介作用:两步多变量孟德尔随机化研究
流行病学研究已经确立了过早性交与故意自残之间的联系。然而,因果机制,特别是精神健康障碍的作用,仍然难以捉摸。方法在这项孟德尔随机化(MR)研究中,我们利用了来自多个来源的全基因组关联研究数据。首次性行为年龄(AFSI)的统计数据来自英国生物银行,涵盖了406,457名欧洲血统的参与者。故意自残(ISH)全基因组关联研究(GWAS)数据来自FinnGen生物银行,其中包括218,792名欧洲人后裔。我们调查了AFSI和ISH之间的因果关系,并量化了重度抑郁障碍(MDD;n = 173,005),精神分裂症(SCZ;n = 127,906),注意缺陷多动障碍(ADHD;n = 55,374)。采用两步和多变量MR方法来估计这些精神障碍的中介作用。结果所有保留的snp的f统计量均大于10,表明我们的研究没有弱的工具偏倚。比值比(OR)显示,过早性交显著增加ISH的风险(IVW: OR = 0.60, 95% CI = 0.54-0.66, p <;0.05)。具体来说,MDD介导了31%的影响,SCZ介导了12%的影响,总共占总影响的46%。结论:过早性交与故意自残的风险增加有关,可能由精神疾病介导。这些发现强调了对性行为发生早的青少年进行心理健康筛查和早期干预的必要性。
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来源期刊
Brain and Behavior
Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES
CiteScore
5.30
自引率
0.00%
发文量
352
审稿时长
14 weeks
期刊介绍: Brain and Behavior is supported by other journals published by Wiley, including a number of society-owned journals. The journals listed below support Brain and Behavior and participate in the Manuscript Transfer Program by referring articles of suitable quality and offering authors the option to have their paper, with any peer review reports, automatically transferred to Brain and Behavior. * [Acta Psychiatrica Scandinavica](https://publons.com/journal/1366/acta-psychiatrica-scandinavica) * [Addiction Biology](https://publons.com/journal/1523/addiction-biology) * [Aggressive Behavior](https://publons.com/journal/3611/aggressive-behavior) * [Brain Pathology](https://publons.com/journal/1787/brain-pathology) * [Child: Care, Health and Development](https://publons.com/journal/6111/child-care-health-and-development) * [Criminal Behaviour and Mental Health](https://publons.com/journal/3839/criminal-behaviour-and-mental-health) * [Depression and Anxiety](https://publons.com/journal/1528/depression-and-anxiety) * Developmental Neurobiology * [Developmental Science](https://publons.com/journal/1069/developmental-science) * [European Journal of Neuroscience](https://publons.com/journal/1441/european-journal-of-neuroscience) * [Genes, Brain and Behavior](https://publons.com/journal/1635/genes-brain-and-behavior) * [GLIA](https://publons.com/journal/1287/glia) * [Hippocampus](https://publons.com/journal/1056/hippocampus) * [Human Brain Mapping](https://publons.com/journal/500/human-brain-mapping) * [Journal for the Theory of Social Behaviour](https://publons.com/journal/7330/journal-for-the-theory-of-social-behaviour) * [Journal of Comparative Neurology](https://publons.com/journal/1306/journal-of-comparative-neurology) * [Journal of Neuroimaging](https://publons.com/journal/6379/journal-of-neuroimaging) * [Journal of Neuroscience Research](https://publons.com/journal/2778/journal-of-neuroscience-research) * [Journal of Organizational Behavior](https://publons.com/journal/1123/journal-of-organizational-behavior) * [Journal of the Peripheral Nervous System](https://publons.com/journal/3929/journal-of-the-peripheral-nervous-system) * [Muscle & Nerve](https://publons.com/journal/4448/muscle-and-nerve) * [Neural Pathology and Applied Neurobiology](https://publons.com/journal/2401/neuropathology-and-applied-neurobiology)
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