Chemically Defined Organoid Culture System for Cholangiocyte Differentiation (Adv. Healthcare Mater. 30/2024)

Abstract

Cholangiocyte Organoids

The jewelry box presents the chemically defined hydrogel (PIC) used for cholangiocyte organoid culture. The ring presents the PIC-cultured organoids; these organoids possess more mature cholangiocyte characteristics, such as bile acid (BA) homeostasis depicted on the box surface. Moreover, these mature cholangiocyte organoids effectively modeled the biliary pro-fibrotic response induced by TGFβ. This model is like a diamond ring that will shine on the path of scientific research and preclinical drug screening. More details can be found in article 2401511 by Rosalinde Masereeuw, Bart Spee, and co-workers.