Single and Joint Associations Between Blood Cell-Based Inflammatory Indicator in Early Pregnancy and Risk of Gestational Diabetes Mellitus (GDM): A Prospective Cohort Study

IF 2.5 3区医学 Q3 IMMUNOLOGY

American Journal of Reproductive Immunology Pub Date : 2024-12-03 DOI:10.1111/aji.70021

Yanling Xiao, Haonan Zhang, Songlin An, Rui Yu, Jing Yang, Xingting Zheng, Nian Wu, Lin Tao, Dengqing Liao, Mingyu Deng, Zhongmei Hu, Yijun Liu, Qing Chen, Yuanzhong Zhou

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引用次数: 0

Abstract

Problem

This study aims to introduce the Bayesian kernel machine regression (BKMR) model to explore the single and joint associations between exposure to blood cell-based inflammatory in early pregnant women and gestational diabetes mellitus (GDM).

Method of Study

The study included 536 singleton pregnant women from the Zunyi Birth Cohort. Logistic regression, restricted cubic spline regression, and BKMR were used to investigate single, nonlinear, and combined associations.

Results

In this study, the adjusted odds ratio (OR) of white blood cell (WBC), neutrophil (NEUT), monocyte (MONO), platelet (PLT), neutrophil-to-lymphocyte ratio (NLR), and systemic immune inflammation index (SII) were 2.20 (95% confidence interval [CI]: 1.43–3.37), 2.27 (95% CI: 1.48–3.48), 1.67 (95% CI: 1.09–2.57), 1.66 (95% CI: 1.07–2.58), 1.65 (95% CI: 1.08–2.54), and 1.89 (95% CI: 1.23–2.91), respectively. Nonlinear associations of WBC (cutoff level: 7.91 × 10⁹/L) and NEUT (cutoff level: 5.52 × 10⁹/L) with GDM were also observed. Furthermore, BKMR analysis showed that the risk of GDM was linked with increased levels of blood cell-based inflammatory indicators.

Conclusion

In early pregnancy, multiple blood cell-based inflammatory indicators are significantly positively correlated with the risk of GDM. Specifically, WBC and NEUT counts exhibit the most prominent association with GDM risk. Therefore, more attention should be paid to the inflammation levels of early pregnant women.

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来源期刊

American Journal of Reproductive Immunology 医学-免疫学

CiteScore

6.20

自引率

5.60%

发文量

314

审稿时长

2 months

期刊介绍： The American Journal of Reproductive Immunology is an international journal devoted to the presentation of current information in all areas relating to Reproductive Immunology. The journal is directed toward both the basic scientist and the clinician, covering the whole process of reproduction as affected by immunological processes. The journal covers a variety of subspecialty topics, including fertility immunology, pregnancy immunology, immunogenetics, mucosal immunology, immunocontraception, endometriosis, abortion, tumor immunology of the reproductive tract, autoantibodies, infectious disease of the reproductive tract, and technical news.