Benzoisoxazoles as Privileged Scaffolds in Design and Synthesis of N-Containing Molecules: Recent Update

Abstract

Benzoisoxazoles, with a distinctive 10-π-electron system and significant polarity, readily trigger N-O bond cleavage, enabling multifaceted applications in organic synthesis. Over the past decade, the exponentially increased use of benzoisoxazoles towards the synthesis of highly valuable N-containing scaffolds, especially N-heterocycles, has garnered substantial attention. In this review, we summarize recent developments in the transformation of 2,1- and 1,2-benzoisoxazoles since 2015, highlighting the neglected resemblances of these two nitroxy heterocycles. Key processes in the assorted reactions of benzoisoxazoles, including mechanisms, scope, catalyst-controlled chemodivergence, current limitations, and developmental prospects, are also introduced and discussed.