{"title":"UCNP@SiO2-maltotrios/HMME preparation and properties study","authors":"Chuqiang Yin, Youliang Shen, Wenqiao Wang, Feng Shen, Yuelei Wang, Zengshuai Han, Ting Wang","doi":"10.1007/s42114-024-01096-x","DOIUrl":null,"url":null,"abstract":"<div><p>Bone and joint infections (BJI) are common diseases in the musculoskeletal system, posing significant challenges due to their difficult early diagnosis, prolonged treatment periods, high costs, and potential for severe consequences. Building upon our previous work on maltotriose-modified magnetite nanoparticles (Fe<sub>3</sub>O<sub>4</sub>-maltotriose), we delve deeper into the research, incorporating the photosensitizer HMME. This integration enables targeted diagnosis of infectious lesions while simultaneously killing bacteria for therapeutic intervention. This study presents the development of a precision drug delivery system (UCNP@SiO<sub>2</sub>-maltotrios/HMME) for the treatment of bacterial infections in bones and joints. Through a microemulsion method, we encapsulated mesoporous SiO<sub>2</sub> onto the surface of upconversion nanoparticles (UCNPs). We then loaded the internal space with the photosensitizer porphyrin monomethyl ether (HMME) to release singlet oxygen (<sup>1</sup>O<sub>2</sub>) upon acoustic activation, and externally loaded maltotriose (maltotrios) as a targeting molecule. Our research investigates the HMME drug loading capacity, and singlet oxygen bactericidal capabilities of this material using a rat infection model. We further evaluated its bactericidal efficacy and biosafety through in vitro cell experiments and in vivo animal studies. Our results demonstrate the excellent luminescence properties and normal imaging capabilities of UCNP@SiO<sub>2</sub>-maltotrios/HMME both in vitro and in vivo. Notably, this material exhibits strong precision targeting and antibacterial activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. Moreover, UCNP@SiO<sub>2</sub>-maltotrios/HMME demonstrates no cytotoxicity in cells or organs of mice, indicating its favorable biosafety.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 1","pages":""},"PeriodicalIF":23.2000,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Composites and Hybrid Materials","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s42114-024-01096-x","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, COMPOSITES","Score":null,"Total":0}
引用次数: 0
Abstract
Bone and joint infections (BJI) are common diseases in the musculoskeletal system, posing significant challenges due to their difficult early diagnosis, prolonged treatment periods, high costs, and potential for severe consequences. Building upon our previous work on maltotriose-modified magnetite nanoparticles (Fe3O4-maltotriose), we delve deeper into the research, incorporating the photosensitizer HMME. This integration enables targeted diagnosis of infectious lesions while simultaneously killing bacteria for therapeutic intervention. This study presents the development of a precision drug delivery system (UCNP@SiO2-maltotrios/HMME) for the treatment of bacterial infections in bones and joints. Through a microemulsion method, we encapsulated mesoporous SiO2 onto the surface of upconversion nanoparticles (UCNPs). We then loaded the internal space with the photosensitizer porphyrin monomethyl ether (HMME) to release singlet oxygen (1O2) upon acoustic activation, and externally loaded maltotriose (maltotrios) as a targeting molecule. Our research investigates the HMME drug loading capacity, and singlet oxygen bactericidal capabilities of this material using a rat infection model. We further evaluated its bactericidal efficacy and biosafety through in vitro cell experiments and in vivo animal studies. Our results demonstrate the excellent luminescence properties and normal imaging capabilities of UCNP@SiO2-maltotrios/HMME both in vitro and in vivo. Notably, this material exhibits strong precision targeting and antibacterial activity against Escherichia coli and Staphylococcus aureus. Moreover, UCNP@SiO2-maltotrios/HMME demonstrates no cytotoxicity in cells or organs of mice, indicating its favorable biosafety.
期刊介绍：
Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field.
The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest.
Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials.
Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.
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