The application and prospects of antimicrobial peptides in antiviral therapy

IF 3 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Amino Acids Pub Date : 2024-12-04 DOI:10.1007/s00726-024-03427-0

Fei Yang, Yunqi Ma

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Abstract

Antimicrobial peptides (AMPs) have broad-spectrum antimicrobial activity, enabling them to rapidly detect and eliminate targets. In addition, many AMPs are natural peptides, making them promising candidates for therapeutic drugs. This review discusses the basic properties and mechanisms of action of AMPs, highlighting their ability to disrupt microbial membranes and modulate host immune responses. It also reviews the current state of research into using AMPs against various viral infections, focusing on their therapeutic potential against viruses that contribute to the global health crisis. Despite promising developments, therapies based on AMPs still face challenges such as stability, toxicity, and production costs. In this text, we will discuss these challenges and the latest technological advances aimed at overcoming them. The combination of nanotechnology and bioengineering approaches offers new ways to enhance the delivery, efficacy, and safety of AMPs. We emphasize the importance of further research to fully exploit the potential of AMPs in antiviral therapy, advocating a multifaceted approach that includes optimizing clinical use and exploring synergies with existing antiviral drugs.

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抗菌肽在抗病毒治疗中的应用及展望

抗菌肽（AMPs）具有广谱抗菌活性，使其能够快速检测和消除靶标。此外，许多amp是天然肽，使它们成为治疗药物的有希望的候选者。本文综述了抗菌肽的基本特性和作用机制，重点介绍了它们破坏微生物膜和调节宿主免疫反应的能力。报告还回顾了利用抗菌肽对抗各种病毒感染的研究现状，重点介绍了抗菌肽对抗导致全球健康危机的病毒的治疗潜力。尽管发展前景良好，但基于amp的治疗仍然面临稳定性、毒性和生产成本等挑战。在本文中，我们将讨论这些挑战以及旨在克服这些挑战的最新技术进展。纳米技术和生物工程方法的结合为增强抗菌肽的递送、疗效和安全性提供了新的途径。我们强调进一步研究以充分挖掘抗菌肽在抗病毒治疗中的潜力的重要性，提倡多方面的方法，包括优化临床使用和探索与现有抗病毒药物的协同作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Amino Acids 生物-生化与分子生物学

CiteScore

6.40

自引率

5.70%

发文量

审稿时长

2.2 months

期刊介绍： Amino Acids publishes contributions from all fields of amino acid and protein research: analysis, separation, synthesis, biosynthesis, cross linking amino acids, racemization/enantiomers, modification of amino acids as phosphorylation, methylation, acetylation, glycosylation and nonenzymatic glycosylation, new roles for amino acids in physiology and pathophysiology, biology, amino acid analogues and derivatives, polyamines, radiated amino acids, peptides, stable isotopes and isotopes of amino acids. Applications in medicine, food chemistry, nutrition, gastroenterology, nephrology, neurochemistry, pharmacology, excitatory amino acids are just some of the topics covered. Fields of interest include: Biochemistry, food chemistry, nutrition, neurology, psychiatry, pharmacology, nephrology, gastroenterology, microbiology