Electrochemical sensor based on molecularly imprinted polypyrrole-MWCNTs-OH/covalent organic framework for the detection of ofloxacin in water

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2024-12-03 DOI:10.1007/s00604-024-06860-w

Lijuan Huang, Yuan Luo, Xulin Li, Juan Wu, Qian Long, Li Zheng, Wenlong Liao, Huiming Li, Lingpu Jia, Kunping Liu

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引用次数: 0

Abstract

A platform was developed to accurately detect the content of ofloxacin (OFX) based on molecularly imprinted polypyrrole-MWCNTs-OH/1,3,5-Tris(4-aminophenyl) benzene (TAPB)-2,5-dimethoxybenzene-1,4-dicarboxaldehyde (DMTP)-covalent organic framework (MIP-MWCNTs-OH/COF)–modified glassy carbon electrode (GCE) sensor (MIP-MWCNTs-OH/COF/GCE). The complex of MWCNTs-OH and COF synergistically enhanced the active area and electrochemical signal, based on which a molecularly imprinted membrane was polymerized on its surface to further improve the selectivity. Under optimized conditions, the prepared MIP-MWCNTs-OH/COF/GCE sensor exhibited strong detection performance to OFX in a linear range 1.969 × 10⁻¹¹–9.619 × 10⁻⁹ M with the limit of detection (LOD, 3S/N) of 4.989 × 10⁻¹² M, excellent selectivity, stability, and reproducibility. Furthermore, the MIP-MWCNTs-OH/COF/GCE sensor can be successfully applied to the detection of OFX in lake water and eye drops with a relative standard deviation (RSD) of less than 4.95%, indicating its high potential in practical applications.

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.