Synthesis, characterization, and biological applications of zinc(ii) complexes of the methylthiosalicylate ligand†

IF 2.7 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

New Journal of Chemistry Pub Date : 2024-11-07 DOI:10.1039/D4NJ03927K

Rajesh Pratap, Soni Kumari, Nishtha Chaturvedi, Rajnikant Mishra and Subrato Bhattacharya

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Abstract

A series of Zn(II) complexes, [Zn(MTS)₂(TMEDA)] (1), [Zn(MTS)₂(2,2′-bipy.)] (2), [Zn(MTS)₂(1,10-phen.)] (3) and [Zn(MTS)₂(4,4-bipy.)₂]_n (4), where MTS = methylthiosalicylate, TMEDA = tetramethyl ethylenediamine, bipy. = bipyridyl, and phen. = phenanthroline, have been synthesized and characterized by single crystal X-ray analysis and other spectroscopic techniques. The geometry of complex 3 is distorted square pyramidal around the Zn center, while complex 2 has distorted trigonal bipyramidal geometry. Complexes 1 and 4 show distorted tetrahedral geometry, of which complex 4 has a zig-zag polymeric structure. Due to differences in geometries, these Zn complexes are expected to exhibit differences in their biological activities. We have carried out studies on the DNA and protein binding, anticancer activity and cytotoxicity of these complexes. The anticancer activities were cell-line dependent; however, complex 4 was found to be the most active complex.

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甲基硫代水杨酸配体锌（ii）配合物的合成、表征和生物学应用

一系列Zn（II）配合物，[Zn(MTS)2(TMEDA)] (1), [Zn(MTS)2(2,2 ' -bipy.)] (2), [Zn(MTS)2(1,10-phen.)](3)和[Zn(MTS)2（4,4-bipy.)2]n(4)，其中MTS =甲基硫代水杨酸酯，TMEDA =四甲基乙二胺，bipy.）。=联吡啶和苯。已合成并通过单晶x射线分析和其他光谱技术进行了表征。复合体3的几何形状是围绕Zn中心的扭曲的方形锥体，而复合体2的几何形状是扭曲的三角双锥体。配合物1和4呈畸变四面体几何，其中配合物4具有锯齿状聚合物结构。由于不同的几何形状，这些锌配合物预计会表现出不同的生物活性。我们对这些复合物的DNA和蛋白质结合、抗癌活性和细胞毒性进行了研究。抗肿瘤活性是细胞系依赖性的；然而，络合物4被发现是最活跃的络合物。

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