A photo-triggered dual-gas donor of nitric oxide and hydrogen sulfide with fluorescence for real-time monitoring of its release†

IF 3.6 3区化学 Q2 CHEMISTRY, ANALYTICAL

Analyst Pub Date : 2024-12-03 DOI:10.1039/D4AN01156B

Afeng Hou, Zhenmei Lin, Yongfang Cheng, Yaoping Tang, Qing Chen, Lingfeng Jiang, Li Li and Ziqian Zhang

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Abstract

Multi-gaseous signal molecules play a significant role in regulating various physiological and pathological processes. Therefore, studying the synergistic effects of multi-gas donors on biological systems is essential. However, different types of gas donors vary significantly in terms of gas release, including location, dose, and flux. These variations can have a dramatic impact on the biological effects of the gases and require further analysis for confirmation. Thus, a controllable dual-gas donor that enables self-reporting would be valuable for studying the biological effects of two species of gaseous signal molecules. Herein, we present a novel photo-triggered donor, NHD545, which releases nitric oxide and hydrogen sulfide simultaneously. Furthermore, the dual-gas release from this donor is accompanied by turn-on fluorescence, which could be utilized to monitor the NO and H₂S release by microscopy. With NHD545, it is convenient to investigate the synergistic effect of dual-gas bioavailability in vitro.

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利用荧光实时监测一氧化氮和硫化氢的光触发双气体供体释放

多气体信号分子是调节各种生理病理过程的重要因素。因此，研究多种气体供体对生物系统的协同效应是必要的。然而，不同类型的气体供体在气体释放方面有很大差异，包括位置、剂量和通量。这些变化可能对气体的生物效应产生巨大影响，需要进一步分析以确认。因此，一种能够自我报告的可控双气体供体对于研究两种气体信号分子的生物学效应是有价值的。在这里，我们提出了一种新的光触发供体NHD545，它同时释放一氧化氮和硫化氢。此外，该供体的双气体释放伴随着开启荧光，可用于显微镜下监测NO和h2s的释放。与NHD545配合使用，双气生物利用度的协同效应便于体外研究。

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