Adipocyte heterogeneity and tumor infiltration of adipose tissue in patients with metastatic breast cancer

IF 5.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast Pub Date : 2024-11-26 DOI:10.1016/j.breast.2024.103852

Hava Izci , Gitte Zels , Anirudh Pabba , Marion Maetens , François Richard , Maxim De Schepper , Josephine Van Cauwenberge , Ha-Linh Nguyen , Kristien Borremans , Sophia Leduc , Karen Van Baelen , Sigrid Hatse , Tatjana Geukens , Amena Mahdami , Hans Wildiers , Patrick Neven , Wouter Van Den Bogaert , Giuseppe Floris , Christine Desmedt

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Abstract

Background

The adipose tissue may serve as a source of energy supporting cancer growth and metastasis. Our understanding of the adipocytes which compose the adipose tissue in different anatomical locations of the body as well as potential microscopic tumor infiltration in patients with metastatic breast cancer remains limited. This study therefore investigates regional variations in adipocyte size and adipose tissue tumor infiltration in patients with metastatic breast cancer.

Methods

Within the UPTIDER rapid autopsy program, (NCT04531696), 94 adipose tissue samples from subcutaneous, visceral, retroperitoneal, and mammary depots of 22 patients with metastatic breast cancer were collected and analyzed. Distant adipocyte size was quantified using digital pathology, and tumor infiltration was assessed histologically. Linear mixed quantile regression analyzed the associations between adipocyte size, fat depot type and major histological subtypes.

Results

Distant adipocyte size did not significantly differ across fat depots. A trend towards smaller adipocytes in mammary fat at autopsy versus diagnosis was observed, suggesting potential age and/or treatment effects. Adipocyte size correlated positively with BMI at death, especially in subcutaneous and visceral fat. Visceral fat exhibited higher tumor infiltration, notably in patients with invasive lobular carcinoma (ILC).

Conclusion

This study highlights the relatively uniform adipocyte size across fat depots in patients with metastatic breast cancer, with potential changes in mammary adipocytes over the disease course. The microscopic tumor cell infiltration observed in the visceral fat, mainly for ILC, underscores the need to undertake additional research to understanding the contribution of the adipose tissue in breast cancer metastasis.

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转移性乳腺癌患者的脂肪细胞异质性和肿瘤浸润

脂肪组织可能是支持肿瘤生长和转移的能量来源。我们对构成身体不同解剖部位脂肪组织的脂肪细胞以及转移性乳腺癌患者潜在的显微肿瘤浸润的了解仍然有限。因此，本研究探讨了转移性乳腺癌患者中脂肪细胞大小和脂肪组织肿瘤浸润的区域差异。方法在uptid快速尸检程序（NCT04531696）中，收集和分析了22例转移性乳腺癌患者的皮下、内脏、腹膜后和乳房的94个脂肪组织样本。使用数字病理学定量远处脂肪细胞大小，组织学评估肿瘤浸润。线性混合分位数回归分析了脂肪细胞大小、脂肪储存类型和主要组织学亚型之间的关系。结果脂肪库间远端脂肪细胞大小无显著差异。与诊断相比，尸检观察到乳腺脂肪中脂肪细胞变小的趋势，提示潜在的年龄和/或治疗效果。死亡时脂肪细胞大小与BMI呈正相关，尤其是皮下脂肪和内脏脂肪。内脏脂肪表现出更高的肿瘤浸润，尤其是浸润性小叶癌（ILC）患者。结论：本研究强调了转移性乳腺癌患者脂肪库中脂肪细胞的大小相对均匀，并且在疾病过程中存在乳腺脂肪细胞的潜在变化。在内脏脂肪中观察到的显微肿瘤细胞浸润，主要是ILC，强调需要进行更多的研究来了解脂肪组织在乳腺癌转移中的作用。

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来源期刊

Breast 医学-妇产科学

CiteScore

8.70

自引率

2.60%

发文量

165

审稿时长

59 days

期刊介绍： The Breast is an international, multidisciplinary journal for researchers and clinicians, which focuses on translational and clinical research for the advancement of breast cancer prevention, diagnosis and treatment of all stages.