Hippocampal atrophy over two years in relation to tau, amyloid-β and memory in older adults

IF 3.7 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging Pub Date : 2024-11-23 DOI:10.1016/j.neurobiolaging.2024.11.007

Etienne Aumont , Marc-André Bedard , Aurélie Bussy , Jaime Fernandez Arias , Cecile Tissot , Brandon J. Hall , Joseph Therriault , Nesrine Rahmouni , Jenna Stevenson , Stijn Servaes , Arthur C. Macedo , Paolo Vitali , Nina Margherita Poltronetti , Olga Fliaguine , Lydia Trudel , Serge Gauthier , Mallar M. Chakravarty , Pedro Rosa-Neto

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引用次数: 0

Abstract

In this longitudinal brain imaging study, we aimed to characterize hippocampal tau accumulation and subfield atrophy relative to cortical amyloid-β and memory performance. We measured tau-PET in regions associated with Braak stages I to VI, global amyloid-PET burden, hippocampal subfield volumes and memory assessments from 173 participants aged 55–85. Eighty-six of these participants were tested again two years later. Tau-PET change in the Braak II region, corresponding to the hippocampus and the entorhinal cortex, was significantly associated with the cornu ammonis 1 (CA1) atrophy and memory score. This CA1 atrophy did not significantly mediate the association between tau and memory, nor did global amyloid-PET burden correlate with tau-PET changes in the Braak II region. Longitudinal hippocampal tau accumulation is amyloid-β-independent and co-localized with subfield atrophy. As tau-associated memory decline seems to be independent from hippocampal atrophy, other mechanisms could contribute to the deficit.

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老年人两岁以上海马萎缩与tau蛋白、淀粉样蛋白β和记忆的关系

在这项纵向脑成像研究中，我们旨在表征海马tau积累和亚场萎缩与皮层淀粉样蛋白-β和记忆表现的关系。我们测量了Braak期I至VI期相关区域的tau-PET，全球淀粉样蛋白- pet负荷，海马体亚区体积和173名55-85岁参与者的记忆评估。其中86名参与者在两年后再次接受了测试。海马和内嗅皮质对应的Braak II区Tau-PET变化与羊角氨1 （CA1）萎缩和记忆评分显著相关。这种CA1萎缩并没有显著介导tau蛋白和记忆之间的关联，也没有整体淀粉样蛋白- pet负荷与Braak II区tau- pet变化相关。海马纵向tau积累与淀粉样蛋白β无关，并与亚场萎缩共定位。由于tau相关的记忆衰退似乎与海马体萎缩无关，其他机制可能导致这种缺陷。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Aging 医学-老年医学

CiteScore

8.40

自引率

2.40%

发文量

225

审稿时长

67 days

期刊介绍： Neurobiology of Aging publishes the results of studies in behavior, biochemistry, cell biology, endocrinology, molecular biology, morphology, neurology, neuropathology, pharmacology, physiology and protein chemistry in which the primary emphasis involves mechanisms of nervous system changes with age or diseases associated with age. Reviews and primary research articles are included, occasionally accompanied by open peer commentary. Letters to the Editor and brief communications are also acceptable. Brief reports of highly time-sensitive material are usually treated as rapid communications in which case editorial review is completed within six weeks and publication scheduled for the next available issue.