Diamond-coated quartz crystal microbalance sensors: Challenges in high yield production and enhanced detection of ethanol and sars-cov-2 proteins

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design Pub Date : 2024-12-01 DOI:10.1016/j.matdes.2024.113474

Tibor Izsák , Marian Varga , Michal Kočí , Ondrej Szabó , Kateřina Aubrechtová Dragounová , Gabriel Vanko , Miroslav Gál , Jana Korčeková , Michaela Hornychová , Alexandra Poturnayová , Alexander Kromka

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Abstract

This study presents the technological progress in the deposition of diamond thin films on quartz crystal microbalance (QCM) sensors. The linear antenna microwave plasma chemical vapour deposition (CVD) technique effectively grows thin diamond films on QCM substrates (Dia-QCM) differently oriented on the substrate holder in the deposition chamber, resulting in single-sided and double-sided coated QCMs. Each of these coated QCMs offers a distinctive advantage for sensing applications. The double-sided coated QCM sensors exhibited the most effective performance in ethanol detection, demonstrating approx. a 3-fold and 12-fold higher response than single-sided diamond-coated and bare gold QCM sensors, respectively. Furthermore, the single-sided Dia-QCM aptasensors demonstrated superior performance compared to bare gold QCM sensors, with a 2-fold higher response and a lower detection limit for S-RBD protein (LOD_Dia-QCM = 0.09 pg/mL vs. LOD_Au-QCM = 0.10 pg/mL). In experiments conducted in human plasma, the Dia-QCM aptasensor demonstrated the ability to detect S-RBD protein at concentrations as low as 50 pg/mL, with high percentage recoveries. These results highlight the potential of linear antenna microwave plasma CVD for the mass production of advanced diamond-coated QCM sensors with different diamond film morphologies (porous, micro- or nanocrystalline) for various applications.

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金刚石涂层石英晶体微平衡传感器：在高产量生产和增强检测乙醇和sars-cov-2蛋白方面的挑战

本文介绍了金刚石薄膜在石英晶体微天平传感器上的沉积技术进展。线性天线微波等离子体化学气相沉积（CVD）技术有效地在QCM衬底（Dia-QCM）上生长不同取向的金刚石薄膜，从而获得单面和双面涂层QCM。每一种涂层qcm都为传感应用提供了独特的优势。双面涂层QCM传感器在乙醇检测中表现出最有效的性能，其检测结果约为。比单面金刚石涂层和裸金QCM传感器分别高3倍和12倍。此外，与裸金QCM传感器相比，单面Dia-QCM传感器表现出更优越的性能，响应速度提高2倍，S-RBD蛋白的检出限更低（LODDia-QCM = 0.09 pg/mL vs LODAu-QCM = 0.10 pg/mL）。在人血浆中进行的实验中，Dia-QCM配体传感器能够检测浓度低至50 pg/mL的S-RBD蛋白，回收率高。这些结果突出了线性天线微波等离子体CVD技术在大规模生产具有不同金刚石膜形态（多孔、微晶或纳米晶）的先进金刚石涂层QCM传感器方面的潜力。

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来源期刊

Materials & Design Engineering-Mechanical Engineering

CiteScore

14.30

自引率

7.10%

发文量

1028

审稿时长

85 days

期刊介绍： Materials and Design is a multi-disciplinary journal that publishes original research reports, review articles, and express communications. The journal focuses on studying the structure and properties of inorganic and organic materials, advancements in synthesis, processing, characterization, and testing, the design of materials and engineering systems, and their applications in technology. It aims to bring together various aspects of materials science, engineering, physics, and chemistry. The journal explores themes ranging from materials to design and aims to reveal the connections between natural and artificial materials, as well as experiment and modeling. Manuscripts submitted to Materials and Design should contain elements of discovery and surprise, as they often contribute new insights into the architecture and function of matter.