Preparation, characterization and antibacterial investigation of water-soluble curcumin-chitooligosaccharide complexes

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2024-11-29 DOI:10.1016/j.carbpol.2024.123083

Xingchen Zhai , Yu Guo , Man Shang , Ziyan Guo , Difeng Ren , A.M. Abd El-Aty

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引用次数: 0

Abstract

Curcumin has a wide range of application prospects, with various bioactivities in the food industry and in the biomedical field. However, curcumin has poor water solubility and is sensitive to pH, light and temperature. In this study, curcumin-chitooligosaccharide (CUR-COS) complexes were prepared via mechanochemical methods, and the CUR-COS complex was more soluble after freeze-drying (up to 862-fold greater than that of curcumin). The complex was characterized by SEM, XRD, FT-IR and thermal analysis, and its stability against pH, light and thermal treatment was evaluated. COSs could serve as carriers for curcumin delivery. Additionally, the antibacterial activity of the formed complex was determined. As a result, CUR-COS exhibited significantly better water solubility, enhanced stability, and stronger antibacterial properties than did pure CUR, offering a promising pathway for the extensive application of lipophilic natural products in foods, especially water-based products.

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.