Relación entre varicocele e hipogonadismo o disfunción eréctil: revisión sistemática y metaanálisis

IF 1.2 4区医学 Q3 UROLOGY & NEPHROLOGY

Actas urologicas espanolas Pub Date : 2024-12-01 DOI:10.1016/j.acuro.2024.05.002

S.J. Gonzalez-Daza , A.M. Díaz-Hung , H.A. García-Perdomo

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引用次数: 0

Abstract

Objective

To assess the association between varicocele and hypogonadism, or erectile dysfunction.

Methods

We searched MEDLINE, EMBASE, LILACS, CENTRAL, and other sources. We included cohort, case-control, and cross-sectional studies. The primary outcome was the association between varicocele and hypogonadism, or erectile dysfunction, and the secondary outcome included semen analysis. We assessed the risk of bias with the Newcastle-Ottawa Scale. We performed statistical analysis in Review Manager® 5.3 and reported information about the odds ratio (OR) with a 95% confidence interval. We produced a forest plot for the primary outcome.

Results

We included ten studies in qualitative analysis and six studies in quantitative analysis. Most of the cross-sectional studies showed a low risk of bias, not so for the two case-control studies, which represented a high risk of bias. Most of the reports described a correlation between having varicocele and presenting low testosterone levels: the meta-analysis showed that there is a significant association between varicocele and hypogonadism (OR: 3.27; 95% CI: 1.23-8.68). Regarding varicocele and erectile, only one study showed a significant difference in erectile function in comparison to varicocele patients and men without varicocele.

Conclusion

There is an association between varicocele presence and hypogonadism, although more studies are needed. Besides, not much is reported about an association between varicocele and erectile dysfunction, but impairment can occur through hormone disturbances.

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静脉曲张与性腺功能减退或勃起功能障碍的关系：系统综述和荟萃分析

目的探讨精索静脉曲张与性腺功能减退或勃起功能障碍的关系。方法检索MEDLINE、EMBASE、LILACS、CENTRAL等数据库。我们纳入了队列研究、病例对照研究和横断面研究。主要结果是精索静脉曲张与性腺功能减退或勃起功能障碍之间的关系，次要结果包括精液分析。我们用纽卡斯尔-渥太华量表评估偏倚风险。我们在Review Manager®5.3中进行了统计分析，并以95%的置信区间报告了优势比（OR）的信息。我们制作了一张森林图作为主要结果。结果定性分析纳入10项研究，定量分析纳入6项研究。大多数横断面研究显示低偏倚风险，但两项病例对照研究并非如此，它们代表高偏倚风险。大多数报告描述了精索静脉曲张与低睾酮水平之间的相关性：荟萃分析显示精索静脉曲张与性腺功能减退之间存在显著关联(OR: 3.27；95% ci: 1.23-8.68)。关于精索静脉曲张和勃起，只有一项研究显示，与精索静脉曲张患者和无精索静脉曲张的男性相比，勃起功能有显著差异。结论精索静脉曲张与性腺功能减退之间存在相关性，但仍需进一步研究。此外，关于精索静脉曲张和勃起功能障碍之间的联系的报道不多，但损伤可能通过激素紊乱发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Actas urologicas espanolas UROLOGY & NEPHROLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

46 days

期刊介绍： Actas Urológicas Españolas is an international journal dedicated to urological diseases and renal transplant. It has been the official publication of the Spanish Urology Association since 1974 and of the American Urology Confederation since 2008. Its articles cover all aspects related to urology. Actas Urológicas Españolas, governed by the peer review system (double blinded), is published online in Spanish and English. Consequently, manuscripts may be sent in Spanish or English and bidirectional free cost translation will be provided.