Emotion regulation: From neural circuits to a transdiagnostic perspective

IF 7.5 1区 医学 Q1 BEHAVIORAL SCIENCES
Carmen Morawetz , Florian J. Hemetsberger , Angela R. Laird , Nils Kohn
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Abstract

Emotion regulation is a critical factor implicated in diverse psychopathologies. However, evidence for the transdiagnostic feature of emotion regulation remains inconclusive. This study explored whether emotion regulation warrants designation as a transdiagnostic construct by examining its distinct neural basis compared to constructs within the existing Research Domain Criteria (RDoC) framework and searching for convergent regional brain activity during emotion regulation across psychiatric disorders. Thus, a two-step analysis approach was implemented. First, using coordinate-based meta-analyses, we reanalysed data from ten prior meta-analyses covering current RDoC domains, assessing unique and overlapping brain regions associated with emotion regulation. This analysis included 3.463 experimental contrasts from 78.338 healthy adults. Results indicated that emotion regulation overlapped with each RDoC domain, especially for those related to cognitive and social processes, yet maintained distinct neural patterns, particularly involving the inferior frontal and medial frontal gyrus. Second, in a separate and the most comprehensive meta-analysis to date, we analysed the neural patterns of emotion regulation in clinical populations. This analysis included 3.576 experimental contrasts from 342 participants, contrasting brain activation patterns during emotion regulation in patients suffering from psychiatric disorders with healthy controls. The findings highlighted the dorsomedial prefrontal cortex's role in emotion regulation across psychiatric disorders. Taken together, these findings support the transdiagnostic nature of emotion regulation by demonstrating its unique neural underpinnings within the RDoC framework and across psychiatric disorders. Recognising the critical importance of emotion regulation in both health and disease may help refine diagnostic criteria and develop treatment strategies, improving mental health outcomes through tailored therapeutic approaches.
情绪调节:从神经回路到跨诊断的视角
情绪调节是涉及多种精神病理的关键因素。然而,关于情绪调节的跨诊断特征的证据仍然没有定论。本研究通过与现有研究领域标准(RDoC)框架内的结构相比,考察其独特的神经基础,并在精神疾病的情绪调节过程中寻找收敛的区域大脑活动,探讨了情绪调节是否值得被指定为一种跨诊断结构。因此,采用了两步分析方法。首先,使用基于坐标的元分析,我们重新分析了涵盖当前RDoC域的10个先前元分析的数据,评估了与情绪调节相关的独特和重叠的大脑区域。该分析包括来自78.338名健康成人的3.463个实验对比。结果表明,情绪调节与每个RDoC区域重叠,特别是与认知和社会过程相关的区域,但保持不同的神经模式,特别是涉及额下回和额内回。其次,在一项单独的、迄今为止最全面的荟萃分析中,我们分析了临床人群中情绪调节的神经模式。这项分析包括来自342名参与者的3.576个实验对比,对比了精神疾病患者和健康对照组在情绪调节过程中的大脑激活模式。研究结果强调了背内侧前额叶皮层在精神疾病情绪调节中的作用。综上所述,这些发现通过在RDoC框架和精神疾病中展示其独特的神经基础,支持了情绪调节的跨诊断性质。认识到情绪调节在健康和疾病中至关重要,可能有助于完善诊断标准,制定治疗策略,通过量身定制的治疗方法改善心理健康结果。
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来源期刊
CiteScore
14.20
自引率
3.70%
发文量
466
审稿时长
6 months
期刊介绍: The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.
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