Signal amplification strategy electrochemiluminescence based on porous graphite-phase carbon nitride: A novel ECL sensor for ultrasensitive detection of tigecycline

IF 10.5 2区材料科学 Q1 CHEMISTRY, PHYSICAL

Carbon Pub Date : 2024-11-28 DOI:10.1016/j.carbon.2024.119857

Chao Li , Juan Lu , Yongbo Feng , Yanjia Guo , Jing Wang , Yujia Song , Ruidan Li , Li Tian

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引用次数: 0

Abstract

Tigecycline (TGC) is a third-generation tetracycline antibiotic known for its broad-spectrum antibacterial properties. However, the misuse of tigecycline can lead to significant issues, including environmental concerns and the escalation of drug resistance. Consequently, it is essential to develop an efficient and sensitive detection method for tigecycline. In this study, a novel solid-state electrochemical luminescence sensor was firstly developed for highly sensitive detection of TGC. The sensor incorporated porous graphite-phase carbon nitride (PCN) as a luminescent reagent, triethanolamine (TEA) as a co-reagent, Fe₃O₄ and ZIF-8@Ag NPs as luminescence accelerators, resulting in a robust and stable luminescence signal. Detailed characterization of PCN, comparison of ECL efficiency between PCN and g-C₃N₄, and optimization of experimental conditions were conducted to showcase the superior ECL performance of PCN. The sensor exhibited a linear relationship between the change of ECL signal and the logarithm of tigecycline concentration in the range of 1.0 × 10⁻¹⁴ to 1.0 × 10⁻⁷ mol/L, with a low detection limit of 3.33 × 10⁻¹⁵ mol/L (S/N = 3). Furthermore, the sensor demonstrated excellent stability, selectivity, and reproducibility, making it suitable for detecting TGC in milk samples.

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来源期刊

Carbon 工程技术-材料科学：综合

CiteScore

20.80

自引率

7.30%

发文量

审稿时长

23 days

期刊介绍： The journal Carbon is an international multidisciplinary forum for communicating scientific advances in the field of carbon materials. It reports new findings related to the formation, structure, properties, behaviors, and technological applications of carbons. Carbons are a broad class of ordered or disordered solid phases composed primarily of elemental carbon, including but not limited to carbon black, carbon fibers and filaments, carbon nanotubes, diamond and diamond-like carbon, fullerenes, glassy carbon, graphite, graphene, graphene-oxide, porous carbons, pyrolytic carbon, and other sp2 and non-sp2 hybridized carbon systems. Carbon is the companion title to the open access journal Carbon Trends. Relevant application areas for carbon materials include biology and medicine, catalysis, electronic, optoelectronic, spintronic, high-frequency, and photonic devices, energy storage and conversion systems, environmental applications and water treatment, smart materials and systems, and structural and thermal applications.