Effect of some physiological and technical factors on Effective Dose Estimation of Patients Administered with 18F-FDG in PET/CT

IF 2.8 3区物理与天体物理 Q3 CHEMISTRY, PHYSICAL

Radiation Physics and Chemistry Pub Date : 2024-11-29 DOI:10.1016/j.radphyschem.2024.112438

Nourhan M. Elsoudy , Maha Anwar , Hanan Hussien , Hossam Mahmoud Yassien , Lamiaa Mahmoud Abdelazeez

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Abstract

Whole-body fluorodeoxyglucose F18 (¹⁸F-FDG) is the most common radiopharmaceutical use in PET/CT imaging for cancer staging. Although radiopharmaceutical for PET/CT examination has been acknowledged for its safety and efficacy, the internal dosimetry and effective dose (ED) from the examinations are rarely discussed. Hence, this study aimed to evaluate radiation ED and influencing factors of ¹⁸F-FDG PET/CT in breast cancer and lymphoma patients. The findings contribute to refining imaging protocols, optimizing radiation exposure, and enhancing the clinical utility of PET/CT in cancer diagnostics and monitoring. Significant correlations were observed between PET effective dose and physiological factors such as age, weight, blood glucose level (BLG), and injected dose, particularly in NHL patients, with a strong negative correlation between PET effective dose and tumor-to-liver ratio (TLR). Based on our results, we recommend excluding patients with blood glucose levels below 80 mg/dL from PET/CT protocols. Additionally, to minimize CT effective doses and adhere to the ALARA principle, reducing tube-current modulation is advised, as it significantly impacts DLP values and the overall effective dose in PET/CT procedures.

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来源期刊

Radiation Physics and Chemistry 化学-核科学技术

CiteScore

5.60

自引率

17.20%

发文量

574

审稿时长

12 weeks

期刊介绍： Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.