Macrophage Polarization-Based Biomaterials for Repairing Spinal Cord Injury

IF 9.6 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Materials Letters Pub Date : 2024-11-15 DOI:10.1021/acsmaterialslett.4c0170110.1021/acsmaterialslett.4c01701

Junchao Luo, Wei Hu, Xiang Gao, Jinyu Bai, Lei Sheng, Huilin Yang, Xiao-zhong Zhou* and Qin Shi*,

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Abstract

Spinal cord injury (SCI) remains a serious problem, owing to its severe consequences and therapeutic limitations. It leads to irreversible impairment of both motor and sensory functions, posing a challenge to recovery and imposing an immense socioeconomic burden on patients. Existing treatment strategies for SCI primarily focus on secondary injury, particularly the modulation of the immune microenvironment after SCI. Infiltrating macrophages play a crucial role in regulating inflammation around the injury site. Macrophages alter their functional phenotypes in response to various stimuli. Classically activated macrophages (M1) exacerbate SCI owing to their pro-inflammatory function, whereas alternatively activated macrophages (M2) inhibit the inflammatory response. Therefore, regulating macrophage polarization represents a promising therapeutic strategy for SCI. Several biomaterial-based strategies for repairing SCI have been developed and are constantly being updated with technological advancements owing to their ability to alleviate neuroinflammation and promote neuroregeneration. In this Review, we focus on the role of macrophages in SCI and discuss the recent research progress of biomaterials targeting macrophage-mediated inflammation for repair and regeneration following SCI. Altogether, this Review provides novel insights into the treatment of SCI.

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巨噬细胞极化生物材料修复脊髓损伤

由于其严重的后果和治疗的局限性，脊髓损伤（SCI）仍然是一个严重的问题。它导致运动和感觉功能不可逆转的损害，对康复构成挑战，并给患者带来巨大的社会经济负担。现有的脊髓损伤治疗策略主要集中在继发性损伤，特别是脊髓损伤后免疫微环境的调节。浸润性巨噬细胞在调节损伤部位周围的炎症中起关键作用。巨噬细胞在各种刺激下改变其功能表型。经典活化的巨噬细胞（M1）因其促炎功能而加重脊髓损伤，而选择性活化的巨噬细胞（M2）则抑制炎症反应。因此，调节巨噬细胞极化是一种很有前景的脊髓损伤治疗策略。由于具有减轻神经炎症和促进神经再生的能力，一些基于生物材料的修复SCI的策略已经被开发出来，并且随着技术的进步而不断更新。本文综述了巨噬细胞在脊髓损伤中的作用，并讨论了针对巨噬细胞介导炎症的生物材料在脊髓损伤后修复和再生中的最新研究进展。总之，这篇综述为脊髓损伤的治疗提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.