Multistage Transdermal Nitric Oxide Delivery System for the Efficient Treatment of Androgenic Alopecia

IF 9.6 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Materials Letters Pub Date : 2024-11-06 DOI:10.1021/acsmaterialslett.4c0189110.1021/acsmaterialslett.4c01891

Hui Xing, Xinlin Jiang, Ziyi Zhao, Yuhui Yang, Zhen Wang, Yang Yi, Guodong Sun, Shixin Liu* and Dong Ma*,

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Abstract

Androgenic alopecia (AGA) is a prevalent progressive hair loss condition. The main therapeutic drug, minoxidil, is limited by its poor efficacy and side effects such as contact dermatitis and hypertrichosis. Nitric oxide (NO), an endothelial-derived relaxing factor, promotes angiogenesis and accelerates blood flow, enhancing nutrient supply similar to minoxidil. Accordingly, we utilized a poly(vinyl alcohol) film (PVA) loaded with hyaluronic acid (HA) liposomes to construct a multistage transdermal NO delivery system (PVA@HL/NONOate) for the treatment of AGA. The HA liposomes provided efficient NO loading and extended release, while the PVA film improved skin penetration and sustained NO release, increasing NO bioavailability. Low-concentration NO effectively enhanced hair follicle vitality and repaired blood vessels. Mechanistically, low-concentration NO could treat AGA mainly by regulating the HIF-1 signaling pathway to promote angiogenesis, reducing inflammation by downregulating the expression of TNFRSF9 and IL-6, repairing hair follicles by downregulating the expression of genes in the CXCL5-IL-17 inflammatory axis.

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有效治疗雄激素性脱发的多阶段经皮一氧化氮输送系统

雄激素性脱发（AGA）是一种普遍的进行性脱发状况。主要治疗药物米诺地尔因其疗效差和副作用（如接触性皮炎和多毛）而受到限制。一氧化氮（NO）是一种内皮来源的放松因子，促进血管生成，加速血液流动，增强营养供应，类似于米诺地尔。因此，我们利用负载透明质酸脂质体的聚乙烯醇膜（PVA）构建了一个多级透皮NO递送系统（PVA@HL/NONOate）来治疗AGA。透明质酸脂质体提供了高效的NO加载和缓释，而PVA膜改善了皮肤渗透和持续释放NO，提高了NO的生物利用度。低浓度NO能有效增强毛囊活力，修复血管。机制上，低浓度NO治疗AGA主要通过调控HIF-1信号通路促进血管生成，下调TNFRSF9和IL-6表达减轻炎症，下调CXCL5-IL-17炎症轴基因表达修复毛囊。

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.