[Chronic rhinosinusitis was neither a risk nor a protective factor during the COVID-19 pandemic].

IF 0.8 4区医学 Q4 OTORHINOLARYNGOLOGY

Hno Pub Date : 2025-02-01 Epub Date: 2024-11-29 DOI:10.1007/s00106-024-01534-8

Hilmar Gudziol, Thomas Hummel, Orlando Guntinas-Lichius

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引用次数: 0

Abstract

Background: There are various views in the literature regarding the influence of chronic rhinosinusitis (CRS) as a comorbidity on the occurrence of COVID-19 disease.

Objective: Did CRS prevent or promote infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the coronavirus pandemic?

Materials and methods: We conducted a retrospective case-control study with 252 adult CRS patients who underwent sinus surgery between 2020 and 2023 and a non-CRS control group; both groups were comparable in terms of age and gender. The association between a history of COVID‑19 and CRS according to its phenotype and endotype was examined using cross tables and chi-square tests. We also analyzed self-reported and measured olfactory ability. Additionally, patients were asked about continuous preoperative use of inhaled corticosteroids.

Results: There was no association between CRS and COVID‑19. This applied both to CRS patients with or without nasal polyps (CRSwNP or CRSsNP) and to endotyping according to tissue eosinophilia. The majority of operated CRS patients were CRSwNP patients, predominantly male and younger compared to CRSsNP patients. CRSwNP presented eosinophilia 2.8 times more frequently than CRSsNP. CRSsNP patients had better reported and measured olfactory ability compared to CRSwNP patients. The measured olfactory ability of the CRS patients with COVID‑19 did not differ from that of CRS patients without C‑19. Preoperative use of inhaled corticosteroids was more frequent among CRSwNP patients than CRSsNP patients.

Conclusion: Chronic rhinosinusitis was neither a risk nor a protective factor for COVID‑19.

查看原文本刊更多论文

[在COVID-19大流行期间，慢性鼻窦炎既不是风险因素，也不是保护因素]。

背景：关于慢性鼻窦炎（CRS）作为一种合并症对COVID-19疾病发生的影响，文献中有不同的观点。目的：在冠状病毒大流行期间，CRS是否预防或促进了SARS-CoV-2的感染？材料和方法：我们对2020年至2023年间接受鼻窦手术的252例成人CRS患者和非CRS对照组进行了回顾性病例对照研究；两组在年龄和性别方面具有可比性。采用交叉表和卡方检验检验COVID - 19病史与CRS表型和内型之间的关系。我们还分析了自我报告和测量的嗅觉能力。此外，患者被问及术前是否持续使用吸入性皮质类固醇。结果：CRS与COVID‑19无相关性。这既适用于伴有或不伴有鼻息肉的CRS患者（CRSwNP或CRSsNP），也适用于根据组织嗜酸性粒细胞增多进行内分型。与CRSsNP患者相比，大多数CRS手术患者为CRSwNP患者，以男性为主，年龄较小。CRSwNP出现嗜酸性粒细胞增多的频率是crsssnp的2.8倍。与CRSwNP患者相比，CRSsNP患者报告和测量的嗅觉能力更好。感染COVID - 19的CRS患者的嗅觉能力与未感染C - 19的CRS患者的嗅觉能力没有差异。CRSwNP患者术前吸入糖皮质激素的使用频率高于CRSsNP患者。结论：慢性鼻窦炎既不是COVID - 19的危险因素，也不是保护因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hno 医学-耳鼻喉科学

CiteScore

1.50

自引率

33.30%

发文量

116

审稿时长

4-8 weeks

期刊介绍： HNO is an internationally recognized journal and addresses all ENT specialists in practices and clinics dealing with all aspects of ENT medicine, e.g. prevention, diagnostic methods, complication management, modern therapy strategies and surgical procedures. Review articles provide an overview on selected topics and offer the reader a summary of current findings from all fields of ENT medicine. Freely submitted original papers allow the presentation of important clinical studies and serve the scientific exchange. Case reports feature interesting cases and aim at optimizing diagnostic and therapeutic strategies. Review articles under the rubric ''Continuing Medical Education'' present verified results of scientific research and their integration into daily practice.