Association between cigarette smoking, genetic polymorphism and myelodysplasia: a multicentric case-control study.

IF 2.6 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Medicina Clinica Pub Date : 2024-11-28 DOI:10.1016/j.medcli.2024.09.017

Natalia de Las Heras Rodríguez, Marta Megido Lahera, José Ramón González Porras, Sonia Sánchez Campos, Raquel Díez Láiz, Marta Fuertes Núñez, Fernando Ramos Ortega

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引用次数: 0

Abstract

Background: Both cigarette smoking (CGS), through its role as a benzene source, and some metabolic detoxyfiying enzymes (EDTOX) polymorphisms that hamper its inactivation, are considered as risk factors for the development of myelodysplastic neoplasms (MDS) and related disorders. This study aims to confirm such associations.

Patients and methods: We recruited 61 patients diagnosed with MDS following FAB Group criteria and 180 adults without peripheral blood cytopenia, and we analyzed: i) the crude odds-ratio (OR) for MDS between smokers and non-smokers, ii) the crude OR for MDS between homozygous individuals for the mutation NQO1⁶⁰⁹C-T, or harboring deletions in the genes codyfing for GSTM1 y GSTT1, and those who did not show such genotypes, and iii) the OR for MDS between smokers and non-smokers, adjusted for other potential risk factors.

Results: Our data confirm the association between MDS with a 28 pack-year or greater CGS history (OR 3.10; IC 95% 1.38-6.96). Conversely, we did not observe any association between MDS diagnosis and the EDTOX genotypes analyzed.

Conclusions: Cigarette smoking history is more relevant than EDTOX genotype in MDS etiopathogenesis.

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来源期刊

Medicina Clinica 医学-医学：内科

CiteScore

3.10

自引率

5.10%

发文量

295

审稿时长

22 days

期刊介绍： Medicina Clínica, fundada en 1943, es una publicación quincenal dedicada a la promoción de la investigación y de la práctica clínica entre los especialistas de la medicina interna, así como otras especialidades. Son características fundamentales de esta publicación el rigor científico y metodológico de sus artículos, la actualidad de los temas y, sobre todo, su sentido práctico, buscando siempre que la información sea de la mayor utilidad en la práctica clínica.