A Mendelian Randomization Study about Causal Associations between Tofu Consumption and Stroke as well as Related Subtypes.

IF 2.5 4区 医学 Q3 NEUROSCIENCES
Yan Wang, Yunlong Liu, Mingwu Xia, Shugang Cao
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Abstract

Objective: Consuming soy in the diet is beneficial for health, and tofu possess the richest source of dietary soy. However, the specific association with stroke and related subtypes remains controversial. In this study, the genetic causal relationship among tofu and stroke as well as the subtypes was investigated by utilizing the data in a number of genome-wide association study (GWAS) based on population.

Methods: The tofu intake GWAS analysis is derived from the Medical Research Council (MRC) Integrative Epidemiology Unit at the University of Bristol (MRC-IEU) Consortium. The two-sample Mendelian randomization (MR) study was carried out, utilizing multiple analysis methods to analyze the associations with stroke and related subtypes. The sensitivity, heterogeneity, and potential pleiotropy could be investigated by multiple analysis method.

Results: We found that tofu intake had no causal relationship with stroke. However, in stroke subtype, there is a causal relationship among tofu intake with the risk of intracerebral hemorrhage (ICH) (odds ratio, OR = 1.24 × 10-5, 95% CI: 1.54 × 10-8-9.95 × 10-3, p = 9.300 × 10-4), while tofu intake does not affect the risk of ischemic stroke (OR = 1.07 × 10-1, 95% CI: 3.84 × 10-4-2.97 × 101, p = 4.362 × 10-1) and subarachnoid hemorrhage (SAH) (OR = 3.33 × 10-3, 95% CI: 1.79 × 10-6-6.18, p = 1.373 × 10-1). Both the Mendelian randomization PRESSO (MR-PRESSO) global test and Cochran's Q test did not detect any sensitivity and heterogeneity.

Conclusions: While tofu consumption is associated with a higher risk of ICH, it does not show a significant relationship with ischemic stroke or SAH. The varying effects of tofu on different stroke subtypes underscore the need for considering potential confounding dietary and lifestyle factors in future studies.

豆腐消费与中风及其相关亚型因果关系的孟德尔随机研究。
目的:在饮食中食用大豆有益健康,而豆腐是膳食中大豆来源最丰富的食品。然而,与中风和相关亚型的具体联系仍存在争议。本研究利用多个基于群体的全基因组关联研究(GWAS)数据,探讨豆腐与脑卒中的遗传因果关系及其亚型。方法:豆腐摄入量的GWAS分析来自布里斯托尔大学医学研究委员会(MRC)综合流行病学小组(MRC- ieu)联盟。采用双样本孟德尔随机化(MR)研究,采用多种分析方法分析其与脑卒中及相关亚型的关系。敏感性、异质性和潜在的多效性可通过多元分析法进行考察。结果:豆腐摄入与脑卒中无因果关系。然而,在中风亚型,因果关系在豆腐摄入量与脑出血的风险(我)(优势比,或者= 1.24×纯,95%置信区间CI: 9.95×1.54×10 - 8三分,4 p = 9.300×打败),而豆腐摄入量并不影响缺血性中风的风险(或= 1.07×10 - 1,95%置信区间CI: 3.84×10 - 4 - 2.97×101,p = 4.362×10 - 1)和蛛网膜下腔出血(SAH)(或= 3.33×三分,95%置信区间CI: 1.79×10 - 6 - 6.18,p = 1.373×10 - 1)。孟德尔随机化整体检验和科克伦Q检验均未发现任何敏感性和异质性。结论:虽然豆腐消费与脑出血的高风险相关,但它与缺血性中风或SAH没有显着关系。豆腐对不同中风亚型的不同影响强调了在未来的研究中考虑潜在的混杂饮食和生活方式因素的必要性。
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来源期刊
CiteScore
2.80
自引率
5.60%
发文量
173
审稿时长
2 months
期刊介绍: JIN is an international peer-reviewed, open access journal. JIN publishes leading-edge research at the interface of theoretical and experimental neuroscience, focusing across hierarchical levels of brain organization to better understand how diverse functions are integrated. We encourage submissions from scientists of all specialties that relate to brain functioning.
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