Association of Comorbidity Duration with the Occurrence and Prognosis of Steatotic Liver Disease.

IF 2.5 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Digestive Diseases and Sciences Pub Date : 2025-01-01 Epub Date: 2024-11-29 DOI:10.1007/s10620-024-08723-z
Hyunji Sang, Jihye Lim, Ha Il Kim
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引用次数: 0

Abstract

Background and aims: Steatotic liver disease (SLD) interacts with various comorbidities, impacting outcomes, yet little is known about the duration of comorbidities in SLD occurrence and mortality. We investigated this relationship, focusing on disease predictors and mortality rates.

Approach: Analyzing 2010 and 2015 Korea National Health and Nutrition Examination Survey data for patients aged ≥ 20, we categorized ten comorbidities (hypertension [HTN], diabetes mellitus [DM], dyslipidemia, stroke, myocardial infarction [MI], angina pectoris, asthma, chronic obstructive lung disease [COPD], chronic kidney disease [CKD], and depression) by duration. Association rule mining and logistic regression analyzed the association between SLD occurrence and comorbidity duration, while Cox regression assessed survival.

Results: The analysis included 2,757 SLD and 9,505 non-SLD cases. Association rule mining showed that the shorter duration of DM and dyslipidemia and the longer duration of HTN comprised the top-ranked component for presence of SLD. DM with a duration ≤ 1 year showed higher risk of SLD than longer periods (odds ratio, 11.53), while the duration of cardiovascular disease, lung disease, or CKD was not significantly associated with the presence of SLD. In terms of prognosis, multivariate Cox regression showed that longer HTN and DM durations were significantly associated with increased hazard ratio (HR) beyond 10 years (HR, 2.22 and 2.11, respectively). Cardiovascular disease duration ≤ 5 years and lung disease duration > 5 years showed statistical significance (HR 2.49and 2.38, respectively).

Conclusions: Duration of comorbidities should be considered for comprehensive SLD risk stratification, for both the identification of SLD and the assessment of their prognosis after detection.

脂肪肝共病持续时间与发生及预后的关系。
背景和目的:脂肪变性肝病(SLD)与多种合并症相互作用,影响预后,但对SLD发生和死亡率中合并症的持续时间知之甚少。我们调查了这种关系,重点关注疾病预测因子和死亡率。方法:分析2010年和2015年年龄≥20岁的韩国国民健康与营养调查数据,按持续时间对10种合并症(高血压[HTN]、糖尿病[DM]、血脂异常、中风、心肌梗死[MI]、心绞痛、哮喘、慢性阻塞性肺疾病[COPD]、慢性肾病[CKD]和抑郁症)进行分类。关联规则挖掘和逻辑回归分析了SLD发生与合并症持续时间之间的关系,Cox回归评估了生存率。结果:分析了2757例SLD和9505例非SLD。关联规则挖掘显示,DM和血脂异常持续时间较短和HTN持续时间较长是SLD存在的最重要因素。病程≤1年的糖尿病患者发生SLD的风险高于病程较长的糖尿病患者(优势比为11.53),而心血管疾病、肺部疾病或CKD病程与SLD的存在无显著相关性。在预后方面,多因素Cox回归分析显示,10年以上HTN和DM持续时间越长,风险比(HR)越高(HR分别为2.22和2.11)。心血管疾病持续时间≤5年、肺部疾病持续时间≤5年有统计学意义(HR分别为2.49、2.38)。结论:综合SLD风险分层,无论是对SLD的识别,还是对其发现后的预后评估,都应考虑合并症的持续时间。
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来源期刊
Digestive Diseases and Sciences
Digestive Diseases and Sciences 医学-胃肠肝病学
CiteScore
6.40
自引率
3.20%
发文量
420
审稿时长
1 months
期刊介绍: Digestive Diseases and Sciences publishes high-quality, peer-reviewed, original papers addressing aspects of basic/translational and clinical research in gastroenterology, hepatology, and related fields. This well-illustrated journal features comprehensive coverage of basic pathophysiology, new technological advances, and clinical breakthroughs; insights from prominent academicians and practitioners concerning new scientific developments and practical medical issues; and discussions focusing on the latest changes in local and worldwide social, economic, and governmental policies that affect the delivery of care within the disciplines of gastroenterology and hepatology.
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