Psychophysiological indices of late-life depression: A systematic review

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2024-11-27 DOI:10.1016/j.brainres.2024.149361

Laura Catalano, Francesco Panico, Luigi Trojano, Laura Sagliano

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引用次数: 0

Abstract

Background

Major depression in the older population has a profound impact on patients’ quality of life and is associated with an increased risk of developing several medical illnesses. Psychophysiological methods, such as electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS), and eye-tracking, have provided evidence of physiological changes associated with depression in adult life. However, these aspects have not been thoroughly investigated during late-life (over 60 years of age).

Methods

A systematic review of the scientific literature covering the studies published between 1990 and 2022 was performed to describe the current evidence on easily attainable psychophysiological factors (detected by EEG, fNIRS and eye-tracking) associated with depression in late-life.

Results

Twelve studies were included in the systematic review. The included studies showed some consistent physiological patterns associated with late-life depression, such as brain hypoactivation in frontal and temporal areas and attentional biases toward emotional stimuli. No reliable patterns in EEG asymmetry and power spectrum were found, in contrast to studies on early-life depression.

Limitations

The small number of available studies, together with the heterogeneity in the techniques and methods used, highlight the need for further research to reliably identify the psychophysiological aspects of depression in late-life.

Conclusions

Physiological indices of late-life depression, as assessed by EEG, fNIRS and eye-tracking, may differ from those of early-life. The study of these indices could better clarify the physiological mechanisms underlying late-life depression with possible clinical and research implications. Recommendations for future research are also discussed.

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查看原文本刊更多论文

老年抑郁症的心理生理指标：系统综述。

背景：老年人群中的重度抑郁症对患者的生活质量有着深远的影响，并与患几种医学疾病的风险增加有关。心理生理学方法，如脑电图（EEG）、功能性近红外光谱（fNIRS）和眼动追踪，已经提供了成年人生活中与抑郁相关的生理变化的证据。然而，这些方面并没有在晚年（60岁以上 岁）进行彻底的调查。方法：对1990年至2022年间发表的科学文献进行了系统回顾，以描述目前容易获得的与晚年抑郁相关的心理生理因素（通过脑电图、近红外光谱和眼动追踪检测）的证据。结果：系统评价纳入了12项研究。纳入的研究显示了一些与晚年抑郁相关的一致的生理模式，比如大脑额叶和颞叶区域的活性降低，以及对情绪刺激的注意力偏向。与早期抑郁的研究相比，在脑电图不对称和功率谱方面没有发现可靠的模式。局限性：可用的研究数量少，加上所使用的技术和方法的异质性，强调需要进一步的研究来可靠地确定晚年抑郁症的心理生理方面。结论：脑电图、近红外光谱及眼动仪对老年抑郁症的生理指标评价可能与早期有所不同。这些指标的研究可以更好地阐明老年抑郁症的生理机制，具有一定的临床和研究意义。并对今后的研究提出了建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.