Predicting solitary pulmonary lesions in breast cancer patients using 18fluorodeoxyglucose-positron emission tomography/computed tomography combined with clinicopathological characteristics.

IF 2.6 3区 医学 Q2 RESPIRATORY SYSTEM
Yangyang Xue, Weishu Hou, Yanhui He, Alei Xu, Xiaohu Li
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Abstract

Background: Solitary pulmonary nodules (SPNs) remain difficult to diagnose for clinical therapeutic purposes in patients with a history of breast cancer. This study try to investigate the value of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) combined with clinicopathological predictors for the differential diagnosis of SPNs in breast cancer patients.

Methods: One hundred and twenty breast cancer patients with newly detected SPNs were enrolled in the study and divided into a primary lung cancer (PLC) group and a breast cancer metastasis (BCM) group. The clinicopathological characteristics as well as metabolic and morphological characteristics on 18F-FDG-PET/CT images of 120 patients were retrospectively reviewed. The differences of clinicopathological and 18F-FDG-PET/CT characteristics between the two groups were analyzed, and multivariate analyses for the diagnosis of SPNs were performed.

Results: Clinicopathological terms of carcinoembryonic antigen (CEA) and CA15-3 levels exhibited significant differences between PLC and BCM groups (P = 0.005 and P = 0.001, respectively). Metabolic characteristics of 18F-FDG-PET/CT images included FDG uptake, SUVmax of SPNs, hilar and/or mediastinal lymph node metastasis, SUVmax of hilar and/or mediastinal lymph node, and extrapulmonary metastasis showed significant differences between PLC and BCM groups (P = 0.004, P < 0.001, P = 0.01, P = 0.032 and P = 0.023, respectively). The lobulation sign, spicule sign, and pleural indentation sign were identified as statistically different morphological features of PLC in CT images (all P < 0.001). Among these, the SUVmax of SPNs, lobulation sign, and pleural indentation sign were valuable predictive factors for accurate diagnosis of SPNs in breast cancer patients.

Conclusions: 18F-FDG-PET/CT combined with serum tumor markers are valuable for the diagnosis of SPNs in breast cancer patients.

应用18氟脱氧葡萄糖-正电子发射断层扫描/计算机断层扫描结合临床病理特征预测乳腺癌患者孤立性肺病变
背景:孤立性肺结节(spn)在有乳腺癌病史的患者中仍然难以诊断用于临床治疗目的。本研究旨在探讨18f -氟脱氧葡萄糖(18F-FDG)正电子发射断层扫描/计算机断层扫描(PET/CT)结合临床病理预测因子对乳腺癌患者spn鉴别诊断的价值。方法:选取120例新发现spn的乳腺癌患者作为研究对象,分为原发性肺癌组(PLC)和乳腺癌转移组(BCM)。回顾性分析120例患者的临床病理特征及18F-FDG-PET/CT的代谢和形态学特征。分析两组患者临床病理及18F-FDG-PET/CT特征的差异,并对SPNs的诊断进行多因素分析。结果:PLC组与BCM组癌胚抗原(CEA)、CA15-3临床病理指标差异有统计学意义(P = 0.005、P = 0.001)。18F-FDG-PET/CT图像代谢特征包括FDG摄取、肺门和/或纵隔淋巴结SUVmax、肺门和/或纵隔淋巴结转移、肺门和/或纵隔淋巴结SUVmax、肺外转移,PLC组与BCM组间差异有统计学意义(P = 0.004),肺门和/或纵隔淋巴结的pmax、分叶征、胸膜压入征是准确诊断乳腺癌患者SPNs的重要预测因素。结论:18F-FDG-PET/CT结合血清肿瘤标志物对乳腺癌患者SPNs的诊断有价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Pulmonary Medicine
BMC Pulmonary Medicine RESPIRATORY SYSTEM-
CiteScore
4.40
自引率
3.20%
发文量
423
审稿时长
6-12 weeks
期刊介绍: BMC Pulmonary Medicine is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of pulmonary and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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