Predicting solitary pulmonary lesions in breast cancer patients using ¹⁸fluorodeoxyglucose-positron emission tomography/computed tomography combined with clinicopathological characteristics.

IF 2.6 3区医学 Q2 RESPIRATORY SYSTEM

BMC Pulmonary Medicine Pub Date : 2024-11-29 DOI:10.1186/s12890-024-03418-7

Yangyang Xue, Weishu Hou, Yanhui He, Alei Xu, Xiaohu Li

{"title":"Predicting solitary pulmonary lesions in breast cancer patients using 18fluorodeoxyglucose-positron emission tomography/computed tomography combined with clinicopathological characteristics.","authors":"Yangyang Xue, Weishu Hou, Yanhui He, Alei Xu, Xiaohu Li","doi":"10.1186/s12890-024-03418-7","DOIUrl":null,"url":null,"abstract":"Background: Solitary pulmonary nodules (SPNs) remain difficult to diagnose for clinical therapeutic purposes in patients with a history of breast cancer. This study try to investigate the value of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) combined with clinicopathological predictors for the differential diagnosis of SPNs in breast cancer patients.Methods: One hundred and twenty breast cancer patients with newly detected SPNs were enrolled in the study and divided into a primary lung cancer (PLC) group and a breast cancer metastasis (BCM) group. The clinicopathological characteristics as well as metabolic and morphological characteristics on 18F-FDG-PET/CT images of 120 patients were retrospectively reviewed. The differences of clinicopathological and 18F-FDG-PET/CT characteristics between the two groups were analyzed, and multivariate analyses for the diagnosis of SPNs were performed.Results: Clinicopathological terms of carcinoembryonic antigen (CEA) and CA15-3 levels exhibited significant differences between PLC and BCM groups (P = 0.005 and P = 0.001, respectively). Metabolic characteristics of 18F-FDG-PET/CT images included FDG uptake, SUVmax of SPNs, hilar and/or mediastinal lymph node metastasis, SUVmax of hilar and/or mediastinal lymph node, and extrapulmonary metastasis showed significant differences between PLC and BCM groups (P = 0.004, P < 0.001, P = 0.01, P = 0.032 and P = 0.023, respectively). The lobulation sign, spicule sign, and pleural indentation sign were identified as statistically different morphological features of PLC in CT images (all P < 0.001). Among these, the SUVmax of SPNs, lobulation sign, and pleural indentation sign were valuable predictive factors for accurate diagnosis of SPNs in breast cancer patients.Conclusions: 18F-FDG-PET/CT combined with serum tumor markers are valuable for the diagnosis of SPNs in breast cancer patients.","PeriodicalId":9148,"journal":{"name":"BMC Pulmonary Medicine","volume":"24 1","pages":"595"},"PeriodicalIF":2.6000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Pulmonary Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12890-024-03418-7","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Solitary pulmonary nodules (SPNs) remain difficult to diagnose for clinical therapeutic purposes in patients with a history of breast cancer. This study try to investigate the value of ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) combined with clinicopathological predictors for the differential diagnosis of SPNs in breast cancer patients.

Methods: One hundred and twenty breast cancer patients with newly detected SPNs were enrolled in the study and divided into a primary lung cancer (PLC) group and a breast cancer metastasis (BCM) group. The clinicopathological characteristics as well as metabolic and morphological characteristics on ¹⁸F-FDG-PET/CT images of 120 patients were retrospectively reviewed. The differences of clinicopathological and ¹⁸F-FDG-PET/CT characteristics between the two groups were analyzed, and multivariate analyses for the diagnosis of SPNs were performed.

Results: Clinicopathological terms of carcinoembryonic antigen (CEA) and CA15-3 levels exhibited significant differences between PLC and BCM groups (P = 0.005 and P = 0.001, respectively). Metabolic characteristics of ¹⁸F-FDG-PET/CT images included FDG uptake, SUV_max of SPNs, hilar and/or mediastinal lymph node metastasis, SUV_max of hilar and/or mediastinal lymph node, and extrapulmonary metastasis showed significant differences between PLC and BCM groups (P = 0.004, P < 0.001, P = 0.01, P = 0.032 and P = 0.023, respectively). The lobulation sign, spicule sign, and pleural indentation sign were identified as statistically different morphological features of PLC in CT images (all P < 0.001). Among these, the SUV_max of SPNs, lobulation sign, and pleural indentation sign were valuable predictive factors for accurate diagnosis of SPNs in breast cancer patients.

Conclusions: ¹⁸F-FDG-PET/CT combined with serum tumor markers are valuable for the diagnosis of SPNs in breast cancer patients.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Pulmonary Medicine RESPIRATORY SYSTEM-

CiteScore

4.40

自引率

3.20%

发文量

423

审稿时长

6-12 weeks

期刊介绍： BMC Pulmonary Medicine is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of pulmonary and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.