On December 18, 2023, an M6.2 earthquake shock the Jishishan County (JSSEQ) in the NE Tibetan plateau. In this study, we conducted a comprehensive analysis based on focal mechanism, seismic b-value and local S-wave splitting analysis to investigate the seismogenic structure and stress state associated with the JSSEQ. The focal mechanism solution shows that the JSSEQ occurs at a centroid depth of 13 km and is associated with a node plane dipping to NNE and the other node plane dipping to WSW. The JSSEQ and its aftershocks are dominated by thrust faulting under prominently sub-horizontal WSW-ENE compression, consistent with the regional stress field. We also observe the JSSEQ occurred in the periphery of a low b-value anomaly body and a ~ 2 year decrease of b-value surrounding the mainshock before the occurrence of JSSEQ. The fast directions are sub-parallel to the maximum horizontal compressive stress with an anticlockwise rotation to the north of the Daotanghe-Linxia fault. Combined with the InSAR observation and surface geology, we deduce that the JSSEQ occurred on a highly stressed asperity of a blind NNE-dipping seismogenic fault, under the control of northeastward expansion of the Tibetan plateau. Our results provide important information for understanding the seismogenic structure and dynamic background of this earthquake that occurred in a highly concerned region.