Antibacterial methacrylamide chitosan-modified viscose/poly(ε-caprolactone) hydrogel membranes for wound healing

IF 4.9 2区工程技术 Q1 MATERIALS SCIENCE, PAPER & WOOD

Cellulose Pub Date : 2024-10-26 DOI:10.1007/s10570-024-06241-9

Xueyan Li, Xiuling Hou, Anle Yang, Dekun Li, Fang Zhou

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引用次数: 0

Abstract

Development of antibacterial dressings for wound treatment is especially worthwhile. Herein, ChMA/tannic acid modified viscose or poly(ε-caprolactone) (PCL) fibrous hydrogel membranes with great antibacterial properties were fabricated to accelerate wound healing. The morphology, chemical structure, swelling capacity, degradation, mechanical and antibacterial properties and cell viability of the modified membranes were investigated. The ChMA/tannic acid-modified viscose membranes exhibited a larger swelling ratio of ca. 200% and a lower degradability than the modified-PCL membrane. The tensile strength and elongation at break of the ChMA/tannic acid modified PCL membrane were about 3.2 ± 0.4 MPa and 618.2 ± 18.2%, respectively, larger than the values of the modified viscose membrane. Simultaneously, the ChMA/TA-modified PCL membrane was 98% effective against S. aureus and had a 91% DPPH free radical scavenging capacity. Moreover, the as-prepared modified hydrogel membranes enabled the maintenance of high bioavailability of tannic acid and synchronization with the porous structure of the ChMA hydrogels, which enhanced the wound healing performance in vivo. Considering the better mechanical properties and relatively long-lasting drug release behavior of PCL ultrafine fibers, ChMA/tannic acid-modified PCL hydrogel membranes have great potential in wound dressings.

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来源期刊

Cellulose 工程技术-材料科学：纺织

CiteScore

10.10

自引率

10.50%

发文量

580

审稿时长

3-8 weeks

期刊介绍： Cellulose is an international journal devoted to the dissemination of research and scientific and technological progress in the field of cellulose and related naturally occurring polymers. The journal is concerned with the pure and applied science of cellulose and related materials, and also with the development of relevant new technologies. This includes the chemistry, biochemistry, physics and materials science of cellulose and its sources, including wood and other biomass resources, and their derivatives. Coverage extends to the conversion of these polymers and resources into manufactured goods, such as pulp, paper, textiles, and manufactured as well natural fibers, and to the chemistry of materials used in their processing. Cellulose publishes review articles, research papers, and technical notes.