Diagnostic value of minor salivary gland biopsy for Sjögren's syndrome in children: A monocentric retrospective study over 10 years

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine Pub Date : 2024-11-26 DOI:10.1016/j.jbspin.2024.105825

Fanny Adeline , Ambre Hittinger , Lois Bolko , Catherine Guettier , Isabelle Kone-Paut , Adrien Schvartz

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引用次数: 0

Abstract

Objectives

Minor salivary gland biopsy (MSGB) is a minimally invasive test used in suspected autoimmune diseases. Our study goal was to evaluate diagnostic performance of MSGB in children suspected of Sjögren's syndrome (SS).

Methods

We did a retrospective monocentric study on patients under 18 years old who had a MSGB between October 2011 and December 2021 at Bicêtre University Hospital. Biopsy was considered positive if focus score was positive or Chisholm-Mason score was superior to 2.

Results

Sixty-six MSGB were analysed in SS indication, 23/66 (35%) were positive and 13/23 (57%) were associated with a confirmed final diagnosis. MSGB was sensitive and specific (Se = 81%, Sp = 80), but with low positive and negative predictive value (57% and 7%). Twenty of 64 MSGB also had positive anti-SSA antibodies. Anti-SSA antibodies improved MSGB specificity (98%).

Conclusion

MSGB demonstrates good sensitivity and specificity, but the predictive values and likelihood ratios make it a poor screening test. However, when combined with other criteria such as the presence of anti-SSA antibodies, the specificity of MSGB is improved. A larger prospective study should be carried out to support our results and clarify the good indications for MSGB.

查看原文本刊更多论文

儿童小唾液腺活检对干燥综合征的诊断价值：一项超过10年的单中心回顾性研究。

目的：小涎腺活检（MSGB）是一种用于疑似自身免疫性疾病的微创检查。我们的研究目的是评估MSGB在疑似干燥综合征（SS）儿童中的诊断性能。方法：我们对2011年10月至2021年12月期间在Bicêtre大学医院发生MSGB的18岁以下患者进行了回顾性单中心研究。如果focus评分为阳性或Chisholm-Mason评分高于2分，则认为活检呈阳性。结果：对66例MSGB进行SS适应症分析，23/66（35%）阳性，13/23（57%）与最终确诊相关。MSGB具有敏感性和特异性（Se=81%, Sp=80），但阳性预测值和阴性预测值较低（分别为57%和7%）。64例MSGB中有20例抗ssa抗体阳性。抗ssa抗体提高了MSGB特异性（98%）。结论：MSGB具有良好的敏感性和特异性，但其预测值和似然比较差。然而，当与其他标准（如抗ssa抗体的存在）结合时，MSGB的特异性得到改善。应该进行更大规模的前瞻性研究来支持我们的结果，并澄清MSGB的良好适应症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Joint Bone Spine 医学-风湿病学

CiteScore

4.50

自引率

11.90%

发文量

184

审稿时长

25 days

期刊介绍： Bimonthly e-only international journal, Joint Bone Spine publishes in English original research articles and all the latest advances that deal with disorders affecting the joints, bones, and spine and, more generally, the entire field of rheumatology. All submitted manuscripts to the journal are subjected to rigorous peer review by international experts: under no circumstances does the journal guarantee publication before the editorial board makes its final decision. (Surgical techniques and work focusing specifically on orthopedic surgery are not within the scope of the journal.)Joint Bone Spine is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.