Long-Latency Auditory Evoked Potentials in Adults with Williams Syndrome.

IF 1 4区医学 Q3 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Journal of the American Academy of Audiology Pub Date : 2024-01-01 Epub Date: 2024-11-28 DOI:10.1055/s-0044-1790280

Jacqueline A Nascimento, Liliane A F Silva, Alessandra G Samelli, Carla G Matas

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Abstract

Background: Williams syndrome (WS) is a genetic, multisystemic, neurodevelopmental disorder, in which studies have demonstrated the presence of auditory deficits such as conductive and sensorineural hearing loss, cochlear weakness, and subclinical signs of hearing impairment. However, few studies have assessed this population's central auditory system.

Purpose: To analyze long-latency auditory evoked potential (LLAEP) in adults with WS and compare them with those obtained from neurotypical individuals with no hearing complaints.

Research design: A cross-sectional observational study with subjects who were submitted to LLAEP assessment with the oddball paradigm and tone-burst stimuli.

Study sample: A total of 30 individuals of both sexes, aged 18 to 37 years-15 had WS and comprised the study group (SG) and 15 did not have either the syndrome or hearing complaints and comprised the control group (CG); they were matched for sex and age.

Results: The LLAEP analysis showed larger P1-N1 and P2-N2 amplitudes but smaller N2-P3 amplitude in SG, which also had delayed latencies in all components compared with CG.

Conclusion: Adults with WS had increased neuronal response in identifying stimulus characteristics, attentional difficulties in auditory tasks, and deficits in auditory information processing speed.

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成人威廉姆斯综合征的长潜伏期听觉诱发电位。

背景：威廉姆斯综合征（WS）是一种遗传性、多系统、神经发育障碍，研究表明存在听觉缺陷，如传导性和感音神经性听力损失、耳蜗无力和听力障碍的亚临床症状。然而，很少有研究评估了这一人群的中枢听觉系统。目的：分析成年WS患者的长潜伏期听觉诱发电位（LLAEP），并将其与无听力症状的神经正常个体的LLAEP进行比较。研究设计：一项横断面观察性研究，受试者采用古怪范式和张力爆发刺激进行LLAEP评估。研究样本：共有30名男女，年龄在18至37岁之间，15名患有WS，组成研究组（SG）， 15名既没有综合征也没有听力投诉，组成对照组（CG）；他们的性别和年龄相匹配。结果：LLAEP分析显示SG的P1-N1和P2-N2振幅较大，N2-P3振幅较小，且各成分潜伏期均较CG延迟。结论：成年WS患者在识别刺激特征、听觉任务注意困难和听觉信息加工速度缺陷方面的神经元反应增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Academy of Audiology 医学-耳鼻喉科学

CiteScore

3.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of the American Academy of Audiology (JAAA) is the Academy''s scholarly peer-reviewed publication, issued 10 times per year and available to Academy members as a benefit of membership. The JAAA publishes articles and clinical reports in all areas of audiology, including audiological assessment, amplification, aural habilitation and rehabilitation, auditory electrophysiology, vestibular assessment, and hearing science.