Striding beyond numbness: a non-randomized controlled study of an exercise program for breast cancer patients with chemotherapy-induced peripheral neuropathy.

IF 2.8 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Ruo-Lin Li, Jun-E Liu, Li-Xiao Bai, Ai-Ling Yang, Yu Liu, Fu-Yun Zhao, Lu Chen, Juan Liu
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引用次数: 0

Abstract

Purpose: To investigate the effectiveness of a 13-week combined supervised and home-based exercise program in alleviating the symptoms of chemotherapy-induced peripheral neuropathy (CIPN) in patients with breast cancer (BC).

Methods: In this non-randomized controlled study, 77 patients with BC selected after applying the inclusion and exclusion criteria were allocated to the intervention (n = 37) or control (n = 40) group. Patients in the intervention group underwent a 13-week exercise program consisting of health education and hand and foot exercises combined with aerobic, resistance, and balance training, while those in the control group received usual care. The symptoms of CIPN were assessed at baseline (T0), post-intervention (T1), and 3 months post-intervention (T2). Physical fitness and finger flexibility were assessed at T0 and T1. A generalized estimating equation (GEE) model was used to analyze the repeated measures data.

Results: The results of GEE showed a significant group effect, indicating significant intergroup differences in the total CIPN score and the dimensions of occurrence, severity, disruption, and frequency (all P < 0.05). Moreover, the two groups showed significant differences in finger flexibility and balance at T1 (all P < 0.05).

Conclusions: The exercise program was effective in alleviating the symptoms of CIPN and improved balance and finger dexterity in comparison with the control group. Randomized controlled trials with larger sizes are required to validate these findings.

超越麻木:一项针对化疗引起的周围神经病变乳腺癌患者的运动计划的非随机对照研究。
目的:探讨为期13周的监督和家庭联合运动方案在缓解乳腺癌(BC)患者化疗诱导的周围神经病变(CIPN)症状方面的有效性。方法:在这项非随机对照研究中,根据纳入和排除标准选择77例BC患者分为干预组(n = 37)和对照组(n = 40)。干预组患者接受了为期13周的锻炼计划,包括健康教育和手脚锻炼,结合有氧、阻力和平衡训练,而对照组患者则接受常规护理。在基线(T0)、干预后(T1)和干预后3个月(T2)评估CIPN症状。在T0和T1时评估身体健康和手指灵活性。采用广义估计方程(GEE)模型对重复测量数据进行分析。结果:GEE结果显示组间效应显著,组间CIPN总分、发生、严重程度、中断、频次维度均有显著差异(均P)。结论:与对照组相比,运动方案可有效缓解CIPN症状,改善平衡性和手指灵巧性。需要更大规模的随机对照试验来验证这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Supportive Care in Cancer
Supportive Care in Cancer 医学-康复医学
CiteScore
5.70
自引率
9.70%
发文量
751
审稿时长
3 months
期刊介绍: Supportive Care in Cancer provides members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals, groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients. It covers primarily medical, technical and surgical topics concerning supportive therapy and care which may supplement or substitute basic cancer treatment at all stages of the disease. Nursing, rehabilitative, psychosocial and spiritual issues of support are also included.
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