Rheological properties of pharmaceutical substrates produced with Celugel.

Q3 Medicine
Monika Gasztych, Natalia Jurczak
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Abstract

Background: Hydrogels, containing a large amount of water and exhibiting high biocompatibility, can improve the rheological properties of formulations and adhere well to the application site. In Poland, only 1 hydrogel substrate is currently approved for pharmaceutical compounding: Celugel, based on hydroxyethyl cellulose (HEC).

Objectives: The aim of this study was to investigate how the variation in the raw material composition of Celugel-based hydrogels affects their osmotic pressure values and selected rheological properties.

Material and methods: Ten gel formulations were prepared using a commercial Celugel as the base, with varying percentages of added water, alongside a consistent 5 wt% addition of sucrose. The research methods employed include osmotic pressure, dynamic viscosity, pH measurement, and surface tension using the du Noüy ring tensiometer.

Results: The composition of the formulation has a significant impact on the osmotic pressure. Nearly all of the hydrogels exhibited hyperosmotic characteristics relative to living tissues, with measured osmotic pressure values ranging from 160 mOsm/kg H2O to 1,480 mOsm/kg H2O. As anticipated, the viscosity of the formulations increased proportionally with the growing concentration of Celugel ranging from 2.19 mPa·s to 562.87 mPa·s.

Conclusion: The composition of Celugel significantly influences its rheological properties and osmotic pressure values, with the concentration of the gelling agent being the most impactful factor. The results suggest that Celugel is suitable for use in formulations intended for nasal administration.

用Celugel生产的药物底物的流变性能。
背景:水凝胶含有大量的水,具有很高的生物相容性,可以改善制剂的流变性能,并能很好地粘附在应用部位。在波兰,目前只有一种水凝胶底物被批准用于药物复合:基于羟乙基纤维素(HEC)的Celugel。目的:本研究的目的是研究纤维素基水凝胶的原料组成的变化如何影响其渗透压值和选择的流变学性质。材料和方法:制备了十种凝胶配方,以商业凝胶为基础,加入不同百分比的水,以及一致的5 wt%的蔗糖。采用的研究方法包括渗透压、动态粘度、pH测量和使用du noy环张力计的表面张力。结果:制剂的组成对渗透压有显著影响。几乎所有的水凝胶都表现出相对于活组织的高渗透特性,测量的渗透压值在160 ~ 1480 mOsm/kg H2O之间。正如预期的那样,随着Celugel浓度的增加,配方的粘度成比例地增加,范围从2.19 mPa·s到562.87 mPa·s。结论:凝胶的组成对其流变性能和渗透压值有显著影响,其中胶凝剂的浓度是影响最大的因素。结果表明,Celugel适合用于鼻腔给药的配方。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Polimery w medycynie
Polimery w medycynie Medicine-Medicine (all)
CiteScore
3.30
自引率
0.00%
发文量
9
审稿时长
53 weeks
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